Development and establishment of the novel method for the objective diagnosis of Meniere's disease using advanced MRI techniques

利用先进的 MRI 技术开发和建立客观诊断梅尼埃病的新方法

• 批准号: 22390233
• 负责人: NAGANAWA Shinji
• 金额: $ 9.24万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390233/
• 关键词: 磁気共鳴医学; 耳科学; 高磁場; 造影剤; メニエール病; 磁気共鳴画像; 受信コイル; 内リンパ; 外リンパ; ガドリニウム造影剤; 内リンパ永腫; 内耳疾患; めまい; 難聴

To develop less invasive and robust objective diagnostic method for Meniere’s disease, we developed various methods as follows; custom built dedicated four channel coil which has 2 times SNR compared to commercial coil. Optimal timing of imaging after iv-Gd was 3.5h-4.5h. We developed positive endolymph image (PEI). For the image processing, we developed a method to separately visualize bone, endolymph and perilymph on a single image. We subtractPEI from PPI, resulting in the HYDROPS image. We also developed HYDROPS2 image etc by the subtraction of T2 from PPI. Additionally, we succeeded the semi-quantification of endolymph size by iv-Gd.

为了开发侵入性更小、更可靠的梅尼埃病客观诊断方法，我们开发了以下各种方法：定制专用四通道线圈，其信噪比是市售线圈的2倍。静脉注射Gd后的最佳成像时间为3.5h~4.5h。我们开发了阳性内淋巴成像(PEI)。对于图像处理，我们开发了一种在一幅图像上分别显示骨、内淋巴和外淋巴的方法。我们从PPI中减去PEI，得到水肿图。从PPI中减去T2，生成HYDROPS2图像等。此外，我们还成功地用iv-Gd对内淋巴大小进行了半定量。

项目成果

Contrast Enhancement of the Anterior Eye Segment and Subarachnoid Space: Detection in the Normal State by Heavily T2-weighted 3D FLAIR

• DOI: 10.2463/mrms.10.193
• 发表时间: 2011-01-01
• 期刊: MAGNETIC RESONANCE IN MEDICAL SCIENCES
• 影响因子: 3
• 作者: Naganawa, Shinji;Yamazaki, Masahiro;Nakashima, Tsutomu
• 通讯作者: Nakashima, Tsutomu

Contrast Effect of the Cochlear Perilymph on 3D-FLAIR after Two Different Gadolinium Contrast Agent Administration Techniques at 3 Tesla : Comparison of Intratympanic and Intravenous Gadolinium Injection

3 特斯拉两种不同钆造影剂给药技术后耳蜗外淋巴对 3D-FLAIR 的对比效果：鼓室内和静脉内钆注射的比较

• 发表时间: 2010
• 作者: Yamazaki M;Naganawa S;Tagaya M;Nakashima T.
• 通讯作者: Nakashima T.

Image Evaluation of Endolymphatic Spacein Patients with Meniere's Disease

梅尼埃病患者内淋巴间隙的影像评估

• 发表时间: 2010
• 作者: Nakashima T;Naganawa S,.Sone M,Teranishi M.
• 通讯作者: Naganawa S,.Sone M,Teranishi M.

Diagnostic value of SPIO-mediated breath-hold, black-blood, fluid-attenuated, inversion recovery (BH-BB-FLAIR) imaging in patients with hepatocellular carcinomas.

SPIO 介导的屏气、黑血、液体衰减、反转恢复 (BH-BB-FLAIR) 成像对肝细胞癌患者的诊断价值。

• 发表时间: 2010
• 期刊: Magn Reson Med Sci
• 影响因子: 3
• 作者: Matsushima M;Naganawa S;Ikeda M;Itoh S;Ogawa H;Komada T;Ishigaki S;Kawai H;Suzuki K;Satake H;Iwano S.
• 通讯作者: Iwano S.

Distribution of gadolinium contrast agent in cochlear perilymph: Comparison of intratympanic and intravenous gadolinium injection

钆造影剂在耳蜗外淋巴液中的分布：鼓室内注射与静脉注射钆的比较

• 发表时间: 2011
• 作者: 上村渉;小山博之;組織再生用三次元細胞培養システム;Yamazaki M,NaganawaS,Kawai H,NakashimaT
• 通讯作者: Yamazaki M,NaganawaS,Kawai H,NakashimaT