Development and establishment of the novel method for the objective diagnosis of Meniere's disease using advanced MRI techniques

为了开发微创、可靠的客观诊断方法，我们开发了以下几种方法；定制专用的四通道线圈，与商业线圈相比具有2倍的信噪比。iv-Gd后最佳成像时间为3.5h-4.5h。我们建立了阳性内淋巴显像（PEI）。在图像处理方面，我们开发了一种在单个图像上分别显示骨、内淋巴和淋巴周围的方法。我们从PPI中减去pei，得到HYDROPS图像。我们还通过PPI减去T2生成了HYDROPS2图像等。此外，我们成功地用iv-Gd对内淋巴大小进行了半定量。

To develop less invasive and robust objective diagnostic method for Meniere’s disease, we developed various methods as follows; custom built dedicated four channel coil which has 2 times SNR compared to commercial coil. Optimal timing of imaging after iv-Gd was 3.5h-4.5h. We developed positive endolymph image (PEI). For the image processing, we developed a method to separately visualize bone, endolymph and perilymph on a single image. We subtractPEI from PPI, resulting in the HYDROPS image. We also developed HYDROPS2 image etc by the subtraction of T2 from PPI. Additionally, we succeeded the semi-quantification of endolymph size by iv-Gd.