Experimental research of immunological tolerance in allograft from cadaveric donors for clinical trial

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During the study period, it was revealed in Rhesus monkeys that anti-human thymocyte globulin may reduce the number of T-cell, that chimerism of peripheral blood mononuclear cells (PMBC) can be detected and that bone marrow transplant can be done by perfusion technique. Although chimerism of PBMC was not observed, mixed lymphocyte reaction (MLR) against the donor lymphocytes was significantly reduced compared to that against lymphocytes of third party monkey