Experimental research of immunological tolerance in allograft from cadaveric donors for clinical trial

研究期间发现，抗人胸腺细胞球蛋白可使恒河猴体内的t细胞数量减少，外周血单核细胞嵌合现象明显，并可通过灌注技术进行骨髓移植。虽然未观察到PBMC嵌合现象，但对供体淋巴细胞的混合淋巴细胞反应（MLR）明显低于对第三方淋巴细胞的混合淋巴细胞反应

During the study period, it was revealed in Rhesus monkeys that anti-human thymocyte globulin may reduce the number of T-cell, that chimerism of peripheral blood mononuclear cells (PMBC) can be detected and that bone marrow transplant can be done by perfusion technique. Although chimerism of PBMC was not observed, mixed lymphocyte reaction (MLR) against the donor lymphocytes was significantly reduced compared to that against lymphocytes of third party monkey