Analysis of carcinogenic mechanism of biliary tract cancer from the protein control by ubiquitin ligase Fbw7

考虑胆道癌细胞系的Fbw 7的基因变异，存在α-β-γ的三种亚型，特别是γ的表达水平追踪到其在所有细胞株中均为低优势，以解决Fbw 7在胆道癌发生中的作用。接下来，为了解决胆道癌的蛋白质控制，Fbxw 7条件性KO（CKO）小鼠的小鼠胚胎成纤维细胞（MEF），CDK抑制剂清楚地显示已经通过Fbxw 7的蛋白水解机制接受了复杂的控制。

The gene variation of Fbw7 of a biliary tract cancer cell line was considered, three sorts of isoform(s) of alpha-beta-gamma existed, and especially the expression level of gamma traced that it was low in predominance by all the cell strains in order to solve the role of Fbw7 in a biliary tract cancer occurrence. Next, in order to solve protein control of a biliary tract cancer, the Mouse Embryonic Fibroblast (MEF) of Fbxw7 conditional KO (CKO) mouse, CDK inhibitor showed clearly to have received the complicated control by the proteolytic mechanism by Fbxw7.