Analysis of carcinogenic mechanism of biliary tract cancer from the protein control by ubiquitin ligase Fbw7

从泛素连接酶Fbw7的蛋白调控分析胆道癌的致癌机制

• 批准号: 22390252
• 负责人: KATAYOSE Yu
• 金额: $ 12.23万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390252/
• 关键词: 胆道癌; ユビキチンリガーゼ; Fbw7; 胆管癌; 遺伝子

The gene variation of Fbw7 of a biliary tract cancer cell line was considered, three sorts of isoform(s) of alpha-beta-gamma existed, and especially the expression level of gamma traced that it was low in predominance by all the cell strains in order to solve the role of Fbw7 in a biliary tract cancer occurrence. Next, in order to solve protein control of a biliary tract cancer, the Mouse Embryonic Fibroblast (MEF) of Fbxw7 conditional KO (CKO) mouse, CDK inhibitor showed clearly to have received the complicated control by the proteolytic mechanism by Fbxw7.

考虑胆道癌细胞系的Fbw 7的基因变异，存在α-β-γ的三种亚型，特别是γ的表达水平追踪到其在所有细胞株中均为低优势，以解决Fbw 7在胆道癌发生中的作用。接下来，为了解决胆道癌的蛋白质控制，Fbxw 7条件性KO（CKO）小鼠的小鼠胚胎成纤维细胞（MEF），CDK抑制剂清楚地显示已经通过Fbxw 7的蛋白水解机制接受了复杂的控制。

项目成果

術前診断cStage II胆管癌に対する術前化学放射線療法

术前诊断cStage II胆管癌术前放化疗

• 发表时间: 2012
• 期刊: 癌と化学療法
• 作者: Yasushi Nagata;et.al.;中川 圭
• 通讯作者: 中川 圭

Efficacy of neoadjuvant chemoradiation therapy forclinical Stage II cholangiocarcinoma as apreoperative diagnosis

新辅助放化疗治疗临床II期胆管癌术前诊断的疗效

• 发表时间: 2012
• 期刊: Gan To Kagaku Ryoho
• 作者: Nakagawa K;Katayose Y;Unno M.
• 通讯作者: Unno M.

Phase I Trial of Neoadjuvant Chemoradiation with Gemcitabine and Surgical Resection for Cholangiocarcinoma Patients (NACRAC Study)

• DOI: 10.5754/hge10106
• 发表时间: 2011-11-01
• 期刊: HEPATO-GASTROENTEROLOGY
• 作者: Katayose, Yu;Rikiyama, Toshiki;Unno, Michiaki
• 通讯作者: Unno, Michiaki

StageII胆管癌への術前化学放射線療法の意義

II期胆管癌术前放化疗的意义

• 发表时间: 2012
• 作者: Kono S;Yoshida K;Tomosugi N;Terada T;Hamaya Y;Kanaoka S;Miyajima H;中川圭
• 通讯作者: 中川圭

Lymph Nodes Metastasis is a Risk Factor for Bone Metastasis from Extrahepatic Cholangiocarcinoma

• DOI: 10.5754/hge11806
• 发表时间: 2012-09-01
• 期刊: HEPATO-GASTROENTEROLOGY
• 作者: Katayose, Yu;Nakagawa, Kei;Unno, Michiaki
• 通讯作者: Unno, Michiaki