Prediction of sensitivity and tolerance of anticancer drug for biliary tract cancer by applying a combination of targeted proteomics and metabolomic analyses.

通过应用靶向蛋白质组学和代谢组学分析相结合来预测抗癌药物对胆道癌的敏感性和耐受性。

• 批准号: 22390254
• 负责人: UNNO Michiaki
• 金额: $ 12.23万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390254/
• 关键词: 胆道癌; 膵癌; 塩酸ゲムシタビン; トランスポーター; 薬剤感受性; 薬剤耐性

To predict the effect of anti-cancer drugs, such as gemcitabine in pancreatic cancer and biliary tract cancer, is also crucial to improve QOL of patients not only improve the survival rate. By combination of targeted proteomics and metabolomic analysese, we investigated the quantitation of membrane transporters and enzymes for drug metabolism using the biliary tract cancer and pancreatic cancer cell line. We found that reduced expression of deoxycitidine kinase (dCK) are brought anticancer drug resistance. Now, we are analyzing the surgical specimens of biliary tract cancer and pancreatic cancer and referring to clinical outcome.

预测吉西他滨等抗癌药物在胰腺癌和胆道癌中的疗效，不仅提高生存率，而且对于改善患者的生活质量也至关重要。通过结合靶向蛋白质组学和代谢组学分析，我们研究了使用胆道癌和胰腺癌细胞系进行药物代谢的膜转运蛋白和酶的定量。我们发现脱氧胞苷激酶（dCK）表达减少会带来抗癌药物耐药性。现在，我们正在分析胆道癌和胰腺癌的手术标本并参考临床结果。

项目成果

胆道癌診断バイオマーカー

胆道癌诊断生物标志物

• 发表时间: 2011

Major hepatectomy for perihilar cholangiocarcinoma

• DOI: 10.1007/s00534-009-0206-3
• 发表时间: 2010-07-01
• 期刊: JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
• 影响因子: 3
• 作者: Unno, Michiaki;Katayose, Yu;Egawa, Shinichi
• 通讯作者: Egawa, Shinichi

GC-binding factor 2 interacts with Dishevelled and regulates Wnt signaling pathways in human carcinoma cell lines

• DOI: 10.1002/ijc.25837
• 发表时间: 2011-10-01
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Ohtsuka, Hideo;Oikawa, Masaya;Johnson, Alfred C.
• 通讯作者: Johnson, Alfred C.

Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy

• DOI: 10.1002/bjs.8654
• 发表时间: 2012-04-01
• 期刊: BRITISH JOURNAL OF SURGERY
• 影响因子: 9.6
• 作者: Motoi, F.;Egawa, S.;Unno, M.
• 通讯作者: Unno, M.

胆道癌の化学療法の現況 当科の胆道癌補助療法の現状 中川 圭(東北大学病院 肝胆膵外科)

胆道癌化疗的现状 我科胆道癌辅助治疗的现状 中川敬（东北大学医院肝胆胰外科）

• 发表时间: 2012
• 作者: 片寄 友;海野 倫明
• 通讯作者: 海野 倫明