Establishment of the novel mouse model of metastatic colorectalcancer and identification of the biomarker for tissue-specific metastasis

新型转移性结直肠癌小鼠模型的建立及组织特异性转移生物标志物的鉴定

• 批准号: 22390257
• 负责人: HINOI Takao
• 金额: $ 12.31万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390257/
• 关键词: 小腸大腸肛門外科学; 大腸癌マウスモデル; バイオマーカー; 大腸癌転移マウスモデル

We generated novel mouse model with complex mutation of colorectal cancer-related gene. (1) The appropriate condition for tumor development was optimized. (2) Observation of the tumor by micro-endoscope was performed.(3)Effect of the specific medication on the tumor growth was analyzed. (4) Afterestablishment of the mouse model with K-ras mutation, comprehensive gene profiling analysis of K-ras signaling was performed and its target gene was identified. In conclusion, useful mouse model for the individualized medication of colorectal cancer was established.

我们建立了一种新的大肠癌相关基因复杂突变小鼠模型。(1)优化了肿瘤生长的适宜条件。(2)采用显微内镜观察肿瘤。（3）分析特异性药物对肿瘤生长的影响。(4)建立K-ras基因突变小鼠模型后，对K-ras信号通路进行基因表达谱分析，确定其靶基因。本研究为大肠癌个体化治疗提供了良好的动物模型。

项目成果

Primary lung cancer presenting with metastasis to the colon: a case report.

• DOI: 10.1186/1477-7819-10-127
• 发表时间: 2012-06-28
• 期刊: World journal of surgical oncology
• 影响因子: 3.2
• 作者: Sakai H;Egi H;Hinoi T;Tokunaga M;Kawaguchi Y;Shinomura M;Adachi T;Arihiro K;Ohdan H
• 通讯作者: Ohdan H

Gastrointestinal stromal tumors of the small intestine in pediatric populations: a case report and literature review.

儿科人群小肠胃肠道间质瘤：病例报告和文献综述。

• DOI: 10.1007/s00383-010-2596-3
• 发表时间: 2010
• 期刊: Pediatr Surg Int.
• 作者: Shimomura M;Ikeda S;Takakura Y;Kawaguchi Y;Tokunaga M;Takeda H;Sumitani D;Yoshimitsu M;Hinoi T;Okajima M;Ohdan H.
• 通讯作者: Ohdan H.

Malignant peripheral nerve sheath tumor arising from the greater omentum: case report.

• DOI: 10.1186/1477-7819-9-33
• 发表时间: 2011-03-21
• 期刊: World journal of surgical oncology
• 影响因子: 3.2
• 作者: Miguchi M;Takakura Y;Egi H;Hinoi T;Adachi T;Kawaguchi Y;Shinomura M;Tokunaga M;Okajima M;Ohdan H
• 通讯作者: Ohdan H

Chlorinated drinking water alters carcinogenesis in a mice model of colon cancer

氯化饮用水改变结肠癌小鼠模型的致癌作用

• 发表时间: 2012
• 作者: Sasada T;Hinoi T
• 通讯作者: Hinoi T

トランスレーショナルリサーチに有用な右側および左側結腸進行癌マウスモデルの構築:臓器特異的Apcコンディショナル・ノックアウトマウスの作製とその臨床応用

用于转化研究的右侧和左侧结肠晚期癌症小鼠模型的构建：器官特异性 Apc 条件敲除小鼠的产生及其临床应用

• 发表时间: 2011
• 作者: Amano R;Yamada N;Nakata B;Kimura K;Yashiro M;Ohira M;Hirakawa K;Kenji Minakata.;檜井孝夫
• 通讯作者: 檜井孝夫