Investigation the mechanism and the role of RNA activation by micro RNA in pancreatic cancer

研究微小RNA激活RNA的机制和在胰腺癌中的作用

• 批准号: 22390258
• 负责人: NAGAI Eishi
• 金额: $ 12.06万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390258/
• 关键词: 膵癌; microRNA; IPMN

We investigated miRNA expression in pancreatic cancer. We found miR-10b expression is overexpressed and miR-X(now submitting) expression is inhibited in pancreatic cancer. We also found miR-10b is related with pancreatic cancer invasiveness and its expression is related with poor prognosis.

我们研究了miRNA在胰腺癌中的表达。我们发现在胰腺癌中miR-10b表达过表达，miR-X（现在提交）表达被抑制。我们还发现miR-10b与胰腺癌侵袭性有关，其表达与预后不良有关。

项目成果

Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells

吉西他滨通过激活胰腺癌细胞中的 CMV 启动子协同增强腺病毒基因治疗的效果

• 发表时间: 2010
• 期刊: Cancer Gene Ther
• 影响因子: 6.4
• 作者: Onimaru M;Ohuchida K;Egami T,Mizumoto K;Nagai E;Toma H;Tanaka M
• 通讯作者: Tanaka M

MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis

• DOI: 10.1016/j.surg.2011.06.017
• 发表时间: 2011-11-01
• 期刊: SURGERY
• 影响因子: 3.8
• 作者: Nakata, Kohei;Ohuchida, Kenoki;Tanaka, Masao
• 通讯作者: Tanaka, Masao

Invasive carcinoma derived from intestinal type intraductal papillary mucinous neoplasm is associated with minimal invasion colloid carcinoma, and less invasisve behabiors, leading to better prognosis

源自肠型导管内乳头状粘液性肿瘤的浸润癌与微浸润胶样癌相关，且侵袭行为较少，预后较好

• 发表时间: 2011
• 期刊: Pancreas
• 影响因子: 2.9
• 作者: Nakata K;Ohuchida K;Nagai E;Mizumoto K
• 通讯作者: Mizumoto K

Feasibility and safety of intracorporeal esophagojejunostomy after laparoscopic total gastrectomy: Inverted T-shaped anastomosis using linear staplers

• DOI: 10.1016/j.surg.2012.10.012
• 发表时间: 2013-05-01
• 期刊: SURGERY
• 影响因子: 3.8
• 作者: Nagai, Eishi;Ohuchida, Kenoki;Tanaka, Masao
• 通讯作者: Tanaka, Masao

Senescence in intraductal papillary mucinous neoplasm of the pancreas.

胰腺导管内乳头状粘液性肿瘤的衰老。

• 发表时间: 2011
• 期刊: Human Pathology
• 影响因子: 3.3
• 作者: Anazawa T;Sato Y;Saito T;Tsuchiya T;Kenjo A;Kimura T;Haga J;Miyake M;Waguri S;Hazama A;Gotoh M.;Miyasaka Y et al
• 通讯作者: Miyasaka Y et al