Investigation of molecular machamism of periopearetive oxygen metabolism regulation by hypoxia-inducible factors

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Oxygen is one of the most important vital molecules for almost all higher organism including human beings. In contrast, excessive oxygen is cytotoxic. A bottom line of the perioperative patient care is to maintain oxygen supply/demand within a narrow optimized range. Hypoxia-inducible factors (HIFs) play a central role in regulation of oxygen homeostasis. To investigate the dynamism of perioperative oxygen metabolism from the point of view of HIFs, we have established the experimental systems adopting cultured cells and experimental animals and obtained several experimental results.