Research and Development of Emergency Life Support System

应急生命保障系统的研发

• 批准号: 22390336
• 负责人: ISOYAMA Takashi
• 金额: $ 12.23万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390336/
• 关键词: 救急蘇生学; 救急蘇生; 人工肺; プレプライミング; シリコーン; 表面修飾; プレプライミング人工肺

A new blood pump for next generation Percutaneous Cardio-Pulmonary Support (PCPS) system and a novel surface coating method for silicone membrane hollow fiber by physical adsorption were developed. The new blood pump named Troidal Convolution Pump (TCP) is based on the principle of cascade pump, and perfused 5 L/min and 350 mmHg at 2450 rpm. The blood is given static pressure by the multiple centrifugal forces during spiral turning in the pump room. The inlet of the blood pump is located on the side wall of the pump housing. There are two semicircular blood pump rooms to keep equilibrium in the axis symmetry. There are two pump outlets located at the top surface of the pump in the axial direction to perfuse the blood to the oxygenator. The impeller is suspended by a monopivot bearing for long-term use and driven by magnet coupling using permanent magnets. The impeller consisted of 20 vanes, and its diameter was 66 mm. The authors employed a dense silicone membrane hollow fiber in this study because of its no-plasma-leakage nature. Additionally, newly developed hydrophilic and biocompatible phosphorylcholine surface coated silicone hollow fiber demonstrated low protein adsorption. The relative intensity of protein adsorption using newly developed hydrophilic phosphorylcholine surface was 7.2 % of non-coated surface. The hollowfiber with no plasma leakage contributes to the next-generation portable, preprimed, and long-termsupport ECLS.

研制了一种用于下一代经皮心肺支持(PCPS)系统的新型血泵和一种新型的硅橡胶膜中空纤维物理吸附表面包覆方法。这种新型血泵是基于串联泵的原理设计的，流量为5 L/分，流量为350毫米汞柱，转速为2450rpm。在泵房螺旋转动的过程中，血液受到多重离心力的静态压力。血泵的入口位于泵壳的侧壁。有两个半圆形的血泵室，以保持轴对称的平衡。在泵的轴向上有两个泵出口，用于将血液灌流到氧合器。叶轮由长期使用的单轴轴承悬挂，并由使用永久磁铁的磁力联轴器驱动。该叶轮由20个叶片组成，直径为66 mm。由于其无血浆泄漏的特性，本研究中采用了致密的硅氧烷薄膜中空纤维。此外，新开发的亲水性和生物相容性的磷酰胆碱表面涂层硅酮中空纤维表现出低蛋白质吸附。新开发的亲水性磷胆碱表面对蛋白质的吸附相对强度是未涂层表面的7.2%。没有等离子体泄漏的中空纤维有助于下一代便携式、预涂底漆和长期支持的ECLS。

项目成果

プレプライミング人工肺を目指した緊急生命維持システムの研究開発

针对预充氧器的应急生命保障系统的研发

• 发表时间: 2012
• 作者: 磯山隆;根本功;斎藤逸郎;有吉洸希;石井耕平;井上雄介;福長一義;井街宏;阿部裕輔
• 通讯作者: 阿部裕輔

救急救命システム用の血液ポンプの開発

紧急救生系统血泵的研制

• 发表时间: 2010
• 作者: Sekine K;Fujishima S;Yo K;Kurihara T;Abe S;Sato Y;Hori S;Aikawa N;時偉;Kazuhiko SEKINE;石井耕平;Ishii K;Abe Y;Saito I;I.Saito;Saito I;大橋広宜;石井耕平;阿部裕輔;斎藤逸郎
• 通讯作者: 斎藤逸郎

The helical flow pump with a hydrodynamic levitation impeller

带有流体动力悬浮叶轮的螺旋流泵

• DOI: 10.1007/s10047-012-0659-z
• 发表时间: 2012
• 期刊: J Artif Organs
• 影响因子: 1.3
• 作者: Abe Y;Ishii K;Isoyama T;Saito I;Inoue Y;Ono T;Nakagawa H;Nakano E;Fukazawa K;Ishihara K;Fukunaga K;Ono M;Imachi K
• 通讯作者: Imachi K

ELSS用血液ポンプの開発

ELSS用血泵的开发

• 发表时间: 2012
• 作者: 磯山隆;根本功;斎藤逸郎;有吉洸希;石井耕平;井上雄介;福長一義;井街宏;阿部裕輔;池田 通,立川絵里,権田芳範,上高原理暢,奥田貴俊,柴田恭明,米澤郁穗,黒澤 尚,金子和夫,井奥洪二;大島勇人;有吉洸希,磯山隆,石井耕平,小野俊哉,井上雄介,斎藤逸郎,中川英元,阿部裕輔
• 通讯作者: 有吉洸希,磯山隆,石井耕平,小野俊哉,井上雄介,斎藤逸郎,中川英元,阿部裕輔

Portable heart-lung machine新時代の到来

便携式心肺机新时代已经到来

• 发表时间: 2010
• 作者: 山隆;鎮西恒雄;斎藤逸郎;小野俊哉;河野明正;井上雄介;時偉;中川英元;井街宏;川崎和男;阿部裕輔;井耕平;時偉;阿部裕輔;阿部裕輔;石井耕平;斎藤逸郎;磯山隆
• 通讯作者: 磯山隆