Therapeutic strategy for oral cancer based on hypoxia PET imaging
Therapeutic strategy for oral cancer based on hypoxia PET imaging
批准号:
22390377
负责人:
KITAGAWA Yoshimasa
金额:
$12.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Establishment of genetic hypoxia imaging is very critical for the treatment of oral cancer. The expression of the human sodium-iodide symporter (hNIS) gene is visualized by positron emission tomography (PET) and single photon emission computed tomography (SPECT). Our group has already established cell lines stably expressing hNIS. We established the cancer cell line stably expressing hNIS (HCT116-hNIS line B), and succeeded in imaging the mouse xenograft model by 99mTcO4SPECT. In the future, this model will provide a tool to track tumor metastasis in vivo in mice so that the molecular mechanism involved in metastatic cascade will be elucidated.
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Clinical usefulness of FDG-PET in combination with serum-soluble Inter leukin-2 receptor (sIL-2R) as a prognostic factor in patients with malignant lvmnhoma in the head and neck.
FDG-PET 与血清可溶性白细胞介素 2 受体 (sIL-2R) 联合作为头颈部恶性淋巴瘤患者的预后因素的临床用途。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kitagawa Y, Onodera M, et al.]
通讯作者:
et al.
低酸素応答性レポーター遺伝子安定発現ヒトグリオーマ細胞株の樹立
稳定表达缺氧反应报告基因的人胶质瘤细胞系的建立
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[村井知佳、犬伏正幸, 他]
通讯作者:
他
Clinical usefulness of FDG-PET in combination with serum-soluble Interleukin-2 receptor (sIL-2R) as a prognostic factor in patients with malignant lymphoma in the head and neck
FDG-PET 联合血清可溶性白细胞介素 2 受体 (sIL-2R) 作为头颈部恶性淋巴瘤患者预后因素的临床应用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kitagawa Y, Onodera M, et al]
通讯作者:
et al
FDG-PET to evaluate four types of chronic osteomyelitis of Jaws in combination with conventional imaging modalities.
FDG-PET 结合传统成像方式评估四种类型的慢性颌骨骨髓炎。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Kitagawa Y, Yamazaki Y, et al.]
通讯作者:
et al.
DOI:
10.1038/gt.2011.128
发表时间:
2012-08-01
期刊:
GENE THERAPY
影响因子:
5.1
作者:
[Jin, Y-N, Inubushi, M., Saga, T.]
通讯作者:
Saga, T.
共 35 条
Novel strategy for treatment of oral cancer based on hypoxia imaging
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批准号:19H03845
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
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财政年份:2019
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负责人:KITAGAWA Yoshimasa
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依托单位:
New strategy for oral cancer based on molecular imaging reflecting therapeutic resistance
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批准号:16H05536
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.07万
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财政年份:2016
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负责人:KITAGAWA Yoshimasa
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依托单位:
Cell analysis in saliva by flow cytometry as a new diagnostic target for oral medicine
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批准号:26670854
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2014
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负责人:KITAGAWA Yoshimasa
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依托单位:
New therapeutic strategy for oral cancer based on gene response to hypoxia by molecular imaging
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批准号:25293406
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
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财政年份:2013
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负责人:KITAGAWA Yoshimasa
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依托单位:
Energy metabolism and muscle pathology in swallowing muscles after electric nerve stimulation
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批准号:24659882
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2012
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负责人:KITAGAWA Yoshimasa
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依托单位:
Energy metabolism and muscle pathology in denervated swallowing muscles
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批准号:22659361
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.07万
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财政年份:2010
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负责人:KITAGAWA Yoshimasa
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依托单位:
FDG-PET to evaluate intraarterial chemoradiotherapy as organ preservation protocol in oral squamous cell carcinoma
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批准号:15592103
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2003
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负责人:KITAGAWA Yoshimasa
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依托单位: