Exploration of carbohydrate molecules that regulate malignant behaviors of oral cavity cancer, and application for the development of novel molecular-targeting therapy

口腔癌在老年人中的发病率高，并且随着老龄化社会的扩大，患有癌症的患者数量将增加。本研究通过检测口腔癌组织中N-乙酰氨基葡萄糖转移酶V（GnT-V）的表达水平，并与临床病理资料进行相关性分析。分析显示，GnT-V表达水平下降是口腔癌患者生存结局较差的指标。

The incidence of oral cavity cancers is high in elderly persons, and the number of patients with the cancers will increase in an enlargement of an aging society. It is a well-known fact that oligosaccharide structures are dramatically changed in carcinogenesis including malignant transformation.In this study, the expression levels of N-Acetylglucosaminyltransferase V (GnT-V) in the tissue sections of oral cavity cancers were correlated with the clinicopathological data. The analysis revealed that the deceased GnT-V expression level is an indicator of poorer survival outcome for patients with oral cavity cancers.