Exploration of carbohydrate molecules that regulate malignant behaviors of oral cavity cancer, and application for the development of novel molecular-targeting therapy

探索调节口腔癌恶性行为的碳水化合物分子及其在新型分子靶向治疗开发中的应用

• 批准号: 22390379
• 负责人: ONIZAWA Kojiro
• 金额: $ 12.4万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390379/
• 关键词: 口腔癌; 悪性挙動; 糖鎖医学; 糖転移酵素; 分子標的治療

The incidence of oral cavity cancers is high in elderly persons, and the number of patients with the cancers will increase in an enlargement of an aging society. It is a well-known fact that oligosaccharide structures are dramatically changed in carcinogenesis including malignant transformation.In this study, the expression levels of N-Acetylglucosaminyltransferase V (GnT-V) in the tissue sections of oral cavity cancers were correlated with the clinicopathological data. The analysis revealed that the deceased GnT-V expression level is an indicator of poorer survival outcome for patients with oral cavity cancers.

口腔癌在老年人中的发病率高，并且随着老龄化社会的扩大，患有癌症的患者数量将增加。本研究通过检测口腔癌组织中N-乙酰氨基葡萄糖转移酶V（GnT-V）的表达水平，并与临床病理资料进行相关性分析。分析显示，GnT-V表达水平下降是口腔癌患者生存结局较差的指标。

项目成果

N-acetylglucosamyltransfererase V in oral squamous cell carcinoma correlates with poor prognosis

口腔鳞状细胞癌中的 N-乙酰葡糖淀粉转移酶 V 与不良预后相关

• 发表时间: 2013
• 期刊: submitted for publication
• 作者: Seto K;Uchida F;Baba O;Yamatoji M;Shonozuka K;Karube R;Warabi E;Yanagawa T;Onizawa K;Miyoshi E;Shoda J;Bukawa H
• 通讯作者: Bukawa H

胆石の種類と成因, 日本胆道学会認定指導医養成講座3

胆结石的种类和成因 日本胆道学会认定讲师研修课程3

• 发表时间: 2012
• 作者: 岡田浩介;蕨栄治;正田純一;正田純一
• 通讯作者: 正田純一

Expression of N- acetylglucosaminyltransferase V in intrahepatic cholangiocarcinoma and its association with clinical findings

N-乙酰氨基葡萄糖转移酶V在肝内胆管癌中的表达及其与临床表现的关系

• 发表时间: 2012
• 期刊: Tokyo Joshi Ikadaigaku Zasshi
• 作者: Onuki K;Shoda J;Kawamoto T;Ariizumi S;Yamamoto M
• 通讯作者: Yamamoto M

Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder

• DOI: 10.1007/s00535-013-0813-2
• 发表时间: 2014-04-01
• 期刊: JOURNAL OF GASTROENTEROLOGY
• 影响因子: 6.3
• 作者: Onuki, Kenichiro;Sugiyama, Hiroaki;Shoda, Junichi
• 通讯作者: Shoda, Junichi

Potent In Vitro and In Vivo Antitumor Activity of Sorafenib Against

索拉非尼的有效体外和体内抗肿瘤活性

• 发表时间: 2011
• 期刊: J Gastroenterol
• 影响因子: 6.3
• 作者: Sugiyama;H.;et al.
• 通讯作者: et al.