Influenza surveillance in Myanmar: investigations on emergence of drug resistant strains and clinical pictures of H1N1pdm09

我们调查了2010-2012财年缅甸仰光和内比都社区流行的流感病毒。3年共分离流感病毒643株，其中A/H1N1pdm09 257株，A/H3N2 182株，b 204株。缅甸的流行季节为5 - 11月雨季。对于A/H3N2和B，新的基因变异出现的时间比日本早半年。耐药监测显示，这些年没有发现对奥司他韦耐药的H274Y突变菌株。我们发现了两种耐药乙型流感病毒，它们对扎那米韦和拉奈米韦具有耐药性，并且在NA基因中具有I248G突变。

We investigated influenza viruses circulated in the community in Yangon and Nay Pyi Taw in Myanmar during FY 2010-2012. In total we isolated 643 influenza viruses during three years, and 257 were A/H1N1pdm09, 182 A/H3N2, and 204 B. Epidemic season in Myanmar was from May to November during the rainy season. For A/H3N2 and B, new genetic variants appeared a half year earlier than in Japan. Drug resistant surveillance showed that there was no oseltamivir resistant H274Y mutated strains during the years. We identified two drug resistant influenza B that conferred resistance to zanamivir and lanaimivir, and possessed I248G mutation in the NA gene.