Influenza surveillance in Myanmar: investigations on emergence of drug resistant strains and clinical pictures of H1N1pdm09

缅甸流感监测：H1N1pdm09耐药菌株出现情况调查和临床情况

• 批准号: 22406013
• 负责人: SAITO Reiko
• 金额: $ 11.9万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22406013/
• 关键词: インフルエンザ; ミャンマー; 流行時期; ウイルス遺伝子解析; ウイルス進化; 薬剤耐性; 新型インフルエンザ; 国際研究; 日本; 感染症疫学; 分子疫学; HA遺伝子; NA遺伝子; オセルタミビル; 遺伝子解析; サーベイランス

We investigated influenza viruses circulated in the community in Yangon and Nay Pyi Taw in Myanmar during FY 2010-2012. In total we isolated 643 influenza viruses during three years, and 257 were A/H1N1pdm09, 182 A/H3N2, and 204 B. Epidemic season in Myanmar was from May to November during the rainy season. For A/H3N2 and B, new genetic variants appeared a half year earlier than in Japan. Drug resistant surveillance showed that there was no oseltamivir resistant H274Y mutated strains during the years. We identified two drug resistant influenza B that conferred resistance to zanamivir and lanaimivir, and possessed I248G mutation in the NA gene.

我们调查了2010-2012财年在仰光社区和缅甸Nay Pyi Taw社区中流传的流感病毒。在三年中，我们总共隔离了643种流感病毒，而257个是A/H1N1PDM09、182 A/H3N2和204B。缅甸的流行季节是在雨季的5月至11月。对于A/H3N2和B，新的遗传变体比日本早半年。耐药性监测表明，这几年中没有抗Oseltamivir抗性H274Y突变菌株。我们确定了对Zanamivir和Lanaimivir抗药性的两个耐药性流感B，并在Na基因中具有I248G突变。

项目成果

Identification of Oseltamivir Resistance among Pandemic and Seasonal Influenza A (H1N1) Viruses by an His275Tyr Genotyping Assay Using the Cycling Probe Method

• DOI: 10.1128/jcm.01401-10
• 发表时间: 2011-01-01
• 期刊: JOURNAL OF CLINICAL MICROBIOLOGY
• 影响因子: 9.4
• 作者: Suzuki, Yasushi;Saito, Reiko;Suzuki, Hiroshi
• 通讯作者: Suzuki, Hiroshi

Reduced effectiveness of oseltamivir in children infected with oseltamivir-resistant influenza A(RIN1)viruses with His275Tyr mutation.

奥司他韦对感染具有 His275Tyr 突变的奥司他韦耐药甲型流感 (RIN1) 病毒的儿童的疗效降低。

• 发表时间: 2010
• 期刊: Pediatr Infect Dis J.
• 作者: Saito R;Sato I;Suzuki Y;Baranovich T;Matsuda R;et.al
• 通讯作者: et.al

Genetic Characterization of Human Influenza A (H3N2) Virus in Myanmar, 2007-2011

2007-2011 年缅甸人类甲型流感 (H3N2) 病毒的遗传特征

• 发表时间: 2013
• 作者: Clyde Dapat;齋藤玲子;齋藤孔良;Isolde Dapat;近藤 大貴;鈴木宏
• 通讯作者: 鈴木宏

新潟大学大学院医歯学総合研究科実験病理学(第二病理)

新泻大学医学齿科研究生院实验病理学（第二病理学）

New Genotypes within Respiratory Syncytial Virus Group B Genotype BA in Niigata, Japan

• DOI: 10.1128/jcm.00646-10
• 发表时间: 2010-09-01
• 期刊: JOURNAL OF CLINICAL MICROBIOLOGY
• 影响因子: 9.4
• 作者: Dapat, Isolde C.;Shobugawa, Yugo;Suzuki, Hiroshi
• 通讯作者: Suzuki, Hiroshi