Functional analysis of nectin and afadin system in synaptogenesis

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Neuronal dendrites and their branches dynamically protrude many fine filopodia in the early stages of neuronal development thatgradually establish complex structures, but the role of these dendritic filopodia in dendritic arborization is unknown. The MAGUK family member, ZO-1, was concentrated at the filopodia-filopodia contact sites. Overexpression or knockdown of ZO-1 affected thedynamics of dendritic filopodial protrusions and their interactions, causing abnormaldendrite morphologies. These results indicate that ZO-1 regulates dendritic filopodialdynamics, and therefore dendrite morphogenesis, in cultured neurons.