The role of calmodulin-kinase II in the mechanism of amygdala-dependent learning and memory.

为了研究钙调素激酶II在杏仁核依赖性学习和记忆机制中的作用，我们分析了基因工程小鼠，其突变使该激酶失活。我们发现，钙调素激酶II的激酶活性在杏仁核依赖性学习记忆机制中起主要作用，但其对海马依赖性学习记忆机制的贡献程度不同。这些结果表明，不同类型分子的组合似乎参与了大脑特定区域学习和记忆类型的形成。

）：To examine the role of calmodulin-kinase II in the mechanism of amygdala-dependent learning and memory, we analyzed genetically-engineered mice with a mutation that rendered the kinase inactive. We found that kinase activity of calmodulin-kinase II plays a major role in the mechanism of amygdala-dependent learning and memory, while the extent of its contribution was different from that to the mechanism of hippocampus-dependent learning and memory. These results indicate that combination of different types of molecules seems to be involved in the formation of brain region-specific types of learning and memory.