Neural mechanisms of discrimination of natural sounds learned by guinea pigs in the competition-based training

豚鼠在竞赛训练中辨别自然声音的神经机制

• 批准号: 22500368
• 负责人: OJIMA HISAYUKI
• 金额: $ 2.25万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-10-20 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500368/
• 关键词: auditory cortex; natural sound; discrimination; classical conditining; voltage-sensitive dye; imaging; positive reinforcement; guinea pigs; 音識別; 聴覚皮質; 自然音; 膜電位感受性色素; 時間逆転音; 抑制; 時空間活動パターン; モルモット; 条件付け; 音響要因; オペラント条件付け; 自然識別; 行動実験; 社会行動

The current study is to illustrate changes in global activation pattern after conditioning to a natural sound (footstep, F sound). Our assumption is that behavioral achievement would be linked to changes in cortical network. This was revealed in the voltage sensitive dye optical imaging. Competitive training, in which multiple animals were trained together, facilitated animals to reach reward earlier than competitors. Imaging results showed that obvious differences in cortical activation have not been found between naive and trained animals with F sound. The time-reversed F sound, which is spectrally the same as but temporally reversed from F sound, resulted in reduced peak activation, both in naive and trained animals, but in much more reduction in trained animals. These results suggest that the cortical network which may have been dominantly tuned to F sound suppresses activation by its temporally-modified version more efficiently than the corresponding naive network.

本研究的目的是说明在条件反射到自然声音（脚步声，F音）后，整体激活模式的变化。我们的假设是，行为成就与皮层网络的变化有关。这在电压敏感染料光学成像中被揭示。竞争性训练，即多只动物一起训练，有助于动物比竞争对手更早获得奖励。影像学结果表明，未训练和训练的动物在F音刺激下的皮层激活没有明显差异。时间反转的F音，这是频谱相同，但从F音时间反转，导致减少峰值激活，无论是在幼稚和训练的动物，但在训练的动物减少得多。这些结果表明，皮质网络，这可能是占主导地位的调谐到F音抑制激活其临时修改的版本比相应的天真的网络更有效。

项目成果

State-dependent changes in background discharge of auditory core neurons in freely moving guinea pigs.

自由移动豚鼠听觉核心神经元背景放电的状态依赖性变化。

• 发表时间: 2012
• 作者: Ojima H;Taira M
• 通讯作者: Taira M

Spectral and Temporal Cues for Recognition of Non-harmonic Natural Sounds by Guinea Pigs

豚鼠识别非谐波自然声音的频谱和时间线索

• 发表时间: 2014
• 作者: Ojima H;Tachi E;Taira M and Horikawa J
• 通讯作者: Taira M and Horikawa J

The Auditory Cortex ; Auditory cortical projections to the medial geniculate body

听觉皮层；

• 发表时间: 2011
• 作者: Ojima H;Rouiller EM
• 通讯作者: Rouiller EM

臨床神経科学;一次聴覚野の多感覚性入出力

临床神经科学；初级听觉皮层的多感觉输入和输出

• 发表时间: 2011
• 作者: Ojima H;Rouiller EM;小島久幸
• 通讯作者: 小島久幸

Auditory cortical function Insights from current approaches

听觉皮层功能 对当前方法的见解

• DOI: 10.1121/1.4729579
• 发表时间: 2012
• 期刊: Acoustics Today
• 作者: Schreiner CE;Kanold PO;Ojima H;Shamma SA;and Lomber SG
• 通讯作者: and Lomber SG