Investigation of the role of astrocytic Ca2+ signaling in higher brain functions
Investigation of the role of astrocytic Ca2+ signaling in higher brain functions
批准号:
22500369
负责人:
TANAKA Mika
金额:
$2.66万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
To examine the role of astrocytic Ca^<2+> signaling in higher brain functions, we generated an inducible transgenic mouse model in which astrocytic Ca^<2+> signaling is attenuated. Attenuated Ca2+ activity correlated with reduced astrocytic coverage of asymmetric synapses in the hippocampal CA1 region in these animals. The decreased astrocytic ‘protection’ of the synapses facilitated glutamate ‘spillover’, and these mice exhibited behavioral impairments in which hippocampal circuits are involved.
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会议论文
Astrocytic IP_3-mediated Ca^<2+> signaling is required for functional integrity of tripartite synapse
星形胶质细胞 IP_3 介导的 Ca^2 信号传导对于三方突触的功能完整性是必需的
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[尾野恭一, 安達健, 佐藤紳一, 岡本洋介, 大場貴喜, 田中三佳]
通讯作者:
田中三佳
Astrocytic calcium signals are required for the functional integrity of tripartite synapses
星形胶质细胞钙信号对于三方突触的功能完整性是必需的
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[小島久幸, 窪田道典, 杉本俊二, 泰羅雅登, 堀川順生, 田中三佳]
通讯作者:
田中三佳
Astrocytic IP_3-mediated Ca^<2+> signaling is required for functional integrity of tripartite synapses
星形胶质细胞 IP_3 介导的 Ca^2 信号传导对于三方突触的功能完整性是必需的
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Ojima H, Tachi E, Taira M and Horikawa J, 田中三佳]
通讯作者:
田中三佳
高校生を対象としたハンセン病に関する人権教育教材の開発と人権教育の実践
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批准号:21H03918
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项目类别:Grant-in-Aid for Encouragement of Scientists
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资助金额:$0.3万
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财政年份:2021
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负责人:TANAKA Mika
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依托单位:
高等学校を対象とした人権教育教材の開発-ハンセン病を題材とした教材冊子の作成-
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批准号:20H00816
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项目类别:Grant-in-Aid for Encouragement of Scientists
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资助金额:$0.31万
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财政年份:2020
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负责人:TANAKA Mika
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依托单位:
The utilize and cost performance of self-medication or alternative medicine in university students
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批准号:22610007
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.41万
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财政年份:2010
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负责人:TANAKA Mika
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依托单位:
Effects of cognitive behavioral therapy for insomnia on depression and cognitive functions among elderly people .
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批准号:22592571
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.25万
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财政年份:2010
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负责人:TANAKA Mika
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依托单位:
海外基金