Identification of genes responsible for resistance/susceptibility toSendai virus infection in the strain difference in mice.

已知实验室小鼠对仙台病毒感染的抗性/易感性存在品系差异。此外，已知基于分别使用C57 BL/6（B6）和DBA/2（D2）小鼠作为抗性和敏感品系的代表的QTL分析，鉴定出三个QTL负责对仙台病毒感染的抗性/敏感性。本研究共获得6个QTLS同源株，其中3个QTLS分别渗入B6和D2小鼠。此外，我们还获得了2个同源品系，其中2个表现上位性互作的QTL分别同时渗入B6和D2小鼠。利用这8个同源株，我们进行了仙台病毒感染实验。结果表明，这3个渗入的QTL均表现出对D2小鼠的抗性，从而证实了这3个QTL中存在着对仙台病毒感染具有抗性的基因。

It is known that there is strain difference in the laboratory mice in the resistance/susceptibility to Sendai virus infection. It is, further, known that three QTLs are identified to be responsible for the resistance/susceptibility to Sendai virus infection, based on the QTL analysis using C57BL/6 (B6) and DBA/2 (D2) mice as a representative of the resistant and susceptible strains, respectively. In this research, we produced 6 congenic strains, in which 3 QTLS were introgressed into B6 and D2 mice, respectively. Further, we produced 2 congenic strains, in which 2 QTLs showing epistatic interaction were simultaneously introgressed into B6 and D2 mice, respectively. Using these 8 congenic strains, we conducted infection experiments with Sendai virus. We obtained results that these three introgressed QTLs invested resistance to D2 mice, thus confirming that genes responsible for resistance to Sendai virus infection should exist in these three QTLs.