Analysis of the pathogenesis of pressure ulcers and development of the preventive and therapeutic measures

压疮发病机制分析及防治措施的制定

• 批准号: 22500461
• 负责人: KAWAMATA Seiichi
• 金额: $ 2.75万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500461/
• 关键词: 褥瘡; 床ずれ; 磁石; 皮膚; 虚血; ラット; 縟瘡; 圧迫

Using our rat model of the pressure ulcers, we examined the effect of varying the magnitude of pressure on the severity of injuries. At 70 and 60 mmHg, edema and skin necrosis were milder than those at 100 mmHg. At 50 mmHg, no or minor focal skin changes were observed in the majority of rats at 50 mmHg, suggesting that prevention of the pressure ulcers is possible by reducing pressure. In spite of the remarkable differences of injuries, the extent of capillary closure was not significantly different between pressures at 50 mmHg and at 60 mmHg or higher. These findings suggest that the severity of injuries is not entirely determined by ischemia due to pressureand other factors possibly play a role in the pathogenesis of pressure ulcers.

使用我们的压疮大鼠模型，我们检查了不同压力大小对损伤严重程度的影响。 70 和 60 mmHg 时，水肿和皮肤坏死较 100 mmHg 时轻。在 50 mmHg 下，大多数大鼠在 50 mmHg 下没有观察到局灶性皮肤变化或观察到轻微的局部皮肤变化，这表明可以通过减压来预防压疮。尽管损伤存在显着差异，但毛细血管闭合程度在 50 mmHg 和 60 mmHg 或更高压力之间没有显着差异。这些发现表明，损伤的严重程度并不完全由压力引起的缺血决定，其他因素可能在压疮的发病机制中发挥作用。

项目成果

Histological findings of uveal capillaries in rabbit eyes after multiple intravitreal injections of bevacizumab

多次玻璃体内注射贝伐珠单抗后兔眼葡萄膜毛细血管的组织学观察

• DOI: 10.3109/02713683.2013.763990
• 发表时间: 2013
• 期刊: Curr Eye Res
• 影响因子: 2
• 作者: Sugimoto Y ;Mochizuki H;Miyagi H;Kawamata S;Kiuchi Y
• 通讯作者: Kiuchi Y

遺体を用いたコ・メディカルの解剖実習:必要性と実習受け入れ側の負担軽減について

使用尸体进行联合医学解剖培训：必要性和减轻接受培训者的负担

• 发表时间: 2011
• 作者: 若宮早央志;高木領,荒川高光,三木明徳;玉越敬悟,石田章真,中島宏樹,嶋田悠,石田和人;川真田 聖一
• 通讯作者: 川真田 聖一

Effect of intravitreal bevacizumab on iris vessels in neovascular glaucoma patients

• DOI: 10.1007/s00417-010-1406-x
• 发表时间: 2010-11-01
• 期刊: GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
• 影响因子: 2.7
• 作者: Sugimoto, Yosuke;Mochizuki, Hideki;Kiuchi, Yoshiaki
• 通讯作者: Kiuchi, Yoshiaki

Gene expression profiles of pressure ulcers ; focus on inflammatory cytokines

压疮的基因表达谱；

• 发表时间: 2011
• 作者: Kurose T;Kawamata S
• 通讯作者: Kawamata S

Experimental pressure ulcers induced by repeated compression using magnets

使用磁铁反复压迫诱发实验性压疮

• 发表时间: 2011
• 作者: Kawamata S;Kurose T;Honkawa Y;Kubori Y,Muramoto H
• 通讯作者: Kubori Y,Muramoto H