Analysis of the pathogenesis of pressure ulcers and development of the preventive and therapeutic measures

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Using our rat model of the pressure ulcers, we examined the effect of varying the magnitude of pressure on the severity of injuries. At 70 and 60 mmHg, edema and skin necrosis were milder than those at 100 mmHg. At 50 mmHg, no or minor focal skin changes were observed in the majority of rats at 50 mmHg, suggesting that prevention of the pressure ulcers is possible by reducing pressure. In spite of the remarkable differences of injuries, the extent of capillary closure was not significantly different between pressures at 50 mmHg and at 60 mmHg or higher. These findings suggest that the severity of injuries is not entirely determined by ischemia due to pressureand other factors possibly play a role in the pathogenesis of pressure ulcers.