Investigation of neurochemical mechanism for the effect of trans-cranial direct current stimulation using multi-modal neuroimaging techniques

利用多模态神经影像技术研究经颅直流电刺激作用的神经化学机制

• 批准号: 22500479
• 负责人: OBAYASHI Shigeru
• 金额: $ 2.83万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500479/
• 关键词: リハビリテーション医学; ニューロリハビリテーション; 機能的近赤外線スペクトロスコピー; ドーパミンD2受容体; 脳可塑性; ポジトロンCT(PET); ドーパミンD2

we aimed to investigate the neurochemical mechanism for the effect of trans-cranial Direct Current Stimulation (t-DCS) using f-NIRS (functional near-infrared spectroscopy) combined with functional Magnetic Resonance Imaging (f-MRI) and Positron Emission Tomography (PET). We confirmed that the upper limb representation in primary motor area, referred to the international 10/20 system for EEG electrode placement, matched well with the motor map derived from f-MRI. Also, f-NIRS results demonstrated that the increase of [oxy-Hb] during a motor task (repetitive grip and release) was enhanced by anodal t-DCS effect, but after exposure to sulpiride, a dopamine D2 antagonist, the enhancement was interfered. The fact may suggest that the effect of t-DCS could be modulated by dopamine system. The findings might contribute to the improvement of t-DCS effect, in terms of its augmentation and persistency.

本研究旨在通过功能近红外光谱(f-NIRS)结合功能磁共振成像(f-MRI)和正电子发射断层扫描(PET)研究经颅直流电刺激(t-DCS)效应的神经化学机制。参考国际脑电电极放置10/20系统，我们证实，初级运动区的上肢表示与由f-MRI得到的运动图匹配良好。此外，f-NIRS结果显示，在运动任务(重复握持和释放)中，阳极t-DCs效应增强了[oxy-Hb]的增加，但暴露于多巴胺D2拮抗剂舒必利后，这种增加被干扰。提示t-DCs的作用可能受多巴胺系统的调节。这一发现可能有助于改善t-dcs效应，使其增强和持续。

项目成果

ビジュアル脳神経外科1前頭葉・頭頂葉前頭葉・頭頂葉の脳機能イメージング

视觉神经外科 1 额叶/顶叶 额叶/顶叶脑功能成像

• 发表时间: 2010
• 作者: 成相正;細田千尋;大林茂
• 通讯作者: 大林茂

Aberrant superior frontal activity of patients with thalamic lesion: combined SPECT and functional near-infrared spectroscopy studies

丘脑病变患者异常的上额叶活动：SPECT 和功能性近红外光谱联合研究

• 发表时间: 2012
• 作者: Suzuki M;Kirimoto H;Onishi H;YamadaS;Tamaki H;Maruyama A;Yamamoto J;Shigeru obayashi and Yukihiro Hara
• 通讯作者: Shigeru obayashi and Yukihiro Hara

THE EFFECT OF AGING ON MEDIAL FRONTAL ACTIVITYDURING VERBAL FLUENCY MONITORED BY MULTI-CHANNEL NEAR INFRARED SPECTROSCOPY C425

多通道近红外光谱C425监测衰老对语言流利度过程中额叶活动的影响

• 发表时间: 2011
• 作者: Suzuki M;Kirimoto H;Inamura A;YagiM;Omori Y;Yamada S;S. OBAYASHI,Y. HARA
• 通讯作者: S. OBAYASHI,Y. HARA

側運動前野損傷に見られる高次脳機能障害

外侧前运动皮层损伤导致脑功能障碍程度更高

• 发表时间: 2010
• 作者: 大林茂;小川真司;原行弘背
• 通讯作者: 原行弘背

HARA Aberrant superior frontal activity of patients with thalamic lesion: combined SPECT and functionalnear-infrared spectroscopy studies 892

HARA 丘脑病变患者异常的上额叶活动：SPECT 和功能性近红外光谱研究相结合 892

• 发表时间: 2012
• 作者: S. OBAYASHI ;S. KOBAYASHI;Y.
• 通讯作者: Y.