Effects of exercise training and pulsed electromagnetic stimulation on inhibition of muscle and bone loss.

我们研究了重复脉冲磁刺激(RPMS)和机械应力运动训练对幼年和老年大鼠肌肉和骨形成的影响。与对侧后肢相比，RPM在治疗24 h后刺激BMP-2和转化生长因子-β2的基因表达。在老年大鼠中，较高强度的RPM并不上调成骨细胞标志基因的mRNA表达水平。因此，RPM对骨形成相关基因表达水平的有利影响可能与年龄和/或刺激强度有关。

We examined the in vivo effects of repetitive pulsed magnetic stimulation (rPMS) and exercise training with mechanical stress on muscle and bone formation in young and aged rat. The rPMS stimulated mRNA levels of BMP-2 and TGF-β2 after 24 h of treatment compared to the contralateral hindlimb in young rats. In old rats, rPMS at higher intensity did not up-regulate mRNA expression levels of osteoblast marker genes. The beneficial effects of rPMS on gene expression levels related to bone formation may thus be associated with age and/or stimulation intensity.