Effects of exercise training and pulsed electromagnetic stimulation on inhibition of muscle and bone loss.

我们研究了重复脉冲磁刺激（rPMS）和机械应力运动训练对年轻和老年大鼠肌肉和骨形成的体内影响。与对侧后肢相比，rPMS在24小时后刺激了年轻大鼠BMP-2和TGF-β2的mRNA水平。在老龄大鼠中，高强度rPMS没有上调成骨细胞标记基因mRNA的表达水平。因此，rPMS对与骨形成相关的基因表达水平的有益影响可能与年龄和/或刺激强度有关。

We examined the in vivo effects of repetitive pulsed magnetic stimulation (rPMS) and exercise training with mechanical stress on muscle and bone formation in young and aged rat. The rPMS stimulated mRNA levels of BMP-2 and TGF-β2 after 24 h of treatment compared to the contralateral hindlimb in young rats. In old rats, rPMS at higher intensity did not up-regulate mRNA expression levels of osteoblast marker genes. The beneficial effects of rPMS on gene expression levels related to bone formation may thus be associated with age and/or stimulation intensity.