Study of anti-metabolic syndrome effects of cholesteryl ester-n3 PUFA targeting for liver energy metabolism alteration in non-alcoholic steatohepatitis rats.
Study of anti-metabolic syndrome effects of cholesteryl ester-n3 PUFA targeting for liver energy metabolism alteration in non-alcoholic steatohepatitis rats.
批准号:
22500665
负责人:
TAKAYAMA Fusako
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
This study showed that DHA cholesteryl ester and EPA one were useful industrially, as both exerted higher effects to retard the NASH progress approximately 10 times than the respective ethyl ester. By evaluation system to reproduce NASH aggravation by choline deficient high fat diets and besides recurrent intermittent oxygen deficiency stress, it was exhibited that the efficacies resulted from relieving the decreased erythrocyte deformability and the persistent oxidative stress-inflammation.
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DOI:
10.3164/jcbn.12-18
发表时间:
2012-11
期刊:
Journal of clinical biochemistry and nutrition
影响因子:
2.4
作者:
[Pak W, Takayama F, Mine M, Nakamoto K, Kodo Y, Mankura M, Egashira T, Kawasaki H, Mori A]
通讯作者:
Mori A
DHA 製品の開発と機能性評価.
DHA 产品开发和功能评估。
DOI:
--
发表时间:
2010
期刊:
ジャパンフードサイエンス
影响因子:
--
作者:
[万倉三正, 西岡巧志, 加太英明(他5名)]
通讯作者:
加太英明(他5名)
Do Cholinergic Nerves Innervating Rat Mesenteric Arteries Regulate Vascular Tone?
支配大鼠肠系膜动脉的胆碱能神经是否调节血管张力?
DOI:
--
发表时间:
2012
期刊:
Am J Physiol Regul Integr Comp Physiol
影响因子:
--
作者:
[Panot T, Takatori S, Sun P, Zamami Y]
通讯作者:
Zamami Y
NASHをターゲットとする食品の開発
开发针对 NASH 的食品
DOI:
--
发表时间:
2011
期刊:
臨床化学
影响因子:
--
作者:
[高山房子, 中本賀寿夫, 峰麻奈加, 杉本志保, 白穎, 江頭亨, 川崎博巳, 黄堂泰昌, 万倉三正, 岡田茂, 森昭胤]
通讯作者:
森昭胤
Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) a-selective agonists
苯丙酸过氧化物酶体增殖物激活受体(PPAR)α-选择性激动剂的基于结构的设计、合成和非酒精性脂肪性肝炎(NASH)预防作用
DOI:
--
发表时间:
2011
期刊:
Bioorg Med Chem
影响因子:
--
作者:
[Ban S, Kasuga J, Nakagome I, Nobusada H, Takayama F,(他2名)]
通讯作者:
Takayama F,(他2名)
共 8 条
Elucidation of liver mitochondrial failure and autoinflammation with RNA-epigenetics caused by nutrient stress
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批准号:19K11692
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2019
-
负责人:TAKAYAMA Fusako
-
依托单位:
Anti-metabolic syndrome study to regulate liver energy metabolism rupture of NASH
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批准号:25350886
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2013
-
负责人:TAKAYAMA Fusako
-
依托单位:
海外基金