Anti-oxidative and anti-inflammatory effects of spirulina on rat model of non-alcoholic steatohepatitis.
Anti-oxidative and anti-inflammatory effects of spirulina on rat model of non-alcoholic steatohepatitis.
复制标题
DOI：
10.3164/jcbn.12-18
复制
发表时间：
2012-11
影响因子：
2.4
通讯作者：
Mori A
中科院分区：
文献类型：
--
作者：
Pak W;Takayama F;Mine M;Nakamoto K;Kodo Y;Mankura M;Egashira T;Kawasaki H;Mori A
非酒精性脂肪性肝炎（NASH）的发病机制尚不清楚，但积累的数据表明氧化应激以及炎症和免疫之间的关系起着至关重要的作用。螺旋藻是一种富含蛋白质和其他营养元素的蓝绿藻，本研究的目的是研究螺旋藻成分-藻蓝蛋白对NASH大鼠模型的作用。以雄性Wistar大鼠饲养5周缺乏胆碱的高脂饲料（CDHF），并通过亚硝酸钠刺激间歇性低氧血症，建立NASH模型。实验10周后采集血液和肝脏，测定螺旋藻或藻蓝蛋白对NASH模型大鼠的氧化应激损伤及疗效。在NASH模型大鼠中，观察到血浆肝酶和肝纤维化的增加，肝线粒体和白细胞活性氧的产生增加，核因子κ B的激活，淋巴细胞表面抗原比率（CD4+/CD8+）的变化。螺旋藻和藻蓝蛋白的施用明显减轻了这些变化。螺旋藻或藻蓝蛋白可能通过抗氧化和抗炎机制减轻NASH模型大鼠的炎症反应，打破氧化应激和炎症之间的串扰，有效抑制NASH进展。
The pathogenesis of nonalcoholic steatohepatitis (NASH) remains unclear, but accumulating data suggest oxidative stress and the relationship between inflammation and immunity plays a crucial role. The aim of this study is to investigate the spirulina, which is a blue-green algae rich in proteins and other nutritional elements, and its component-phycocyanin effect on a rat model of NASH. NASH model rats were established by feeding male Wistar rats with choline-deficient high-fat diet (CDHF) and intermittent hypoxemia by sodium nitrite challenge after 5 weeks of CDHF. After experimental period of 10 weeks, blood and liver were collected to determine oxidative stress injuries and efficacies of spirulina or phycocyanin on NASH model rats. In the NASH model rats, increase in plasma liver enzymes and liver fibrosis, increases in productions of reactive oxygen species from liver mitochondria and from leukocytes, the activation of nuclear factor-kappa B, and the change in the lymphocyte surface antigen ratio (CD4+/CD8+) were observed. The spirulina and phycocyanin administration significantly abated these changes. The spirulina or phycocyanin administration to model rats of NASH might lessen the inflammatory response through anti-oxidative and anti-inflammatory mechanisms, breaking the crosstalk between oxidative stress and inflammation, and effectively inhibit NASH progression.
登录
查看更多内容
影响因子：
29.4
作者：
Day, CP
通讯作者：
Day, CP
DOI：
10.1590/s0100-879x1998000800007
发表时间：
1998-08-01
影响因子：
2.3
作者：
Miranda, MS;Cintra, RG;Mancini, J
通讯作者：
Mancini, J
影响因子：
2.4
作者：
Mao, T K;VAN DE Water, J;Gershwin, M E
通讯作者：
Gershwin, M E
影响因子：
15.9
作者：
Leclercq, IA;Farrell, GC;Robertson, GR
通讯作者：
Robertson, GR
影响因子：
29.4
作者：
Matteoni, CA;Younossi, ZM;McCullough, AJ
通讯作者：
McCullough, AJ