The mechanism of obesity establishment in the ovariectomized rat

众所周知，卵巢切除（OVX）大鼠在OVX后会增加体脂。然而，肥胖形成的机制仍不清楚。本研究的目的是揭示这一点，通过3个月的观察，OVX组的体重显著增加。OVX组在前2个月摄食量显著增加，此后与Sham组基本持平。因此，我们不能断言，只有增加的食物消费带来肥胖。然后，我们测量体温作为能量代谢的指标。与Sham组相比，OVX组的体温显著降低。这一现象表明OVX组的能量代谢低于Sham组。这些结果表明，在OVX大鼠肥胖的原因是能量代谢的下降，除了增加的食物消耗。

It is well known that ovariectomized(OVX) rats gain the body fat after OVX. However, the mechanism of obesity establishment is still unknown enough yet. The aim of this study is to reveal about it. The body weight of OVX group increased remarkably through 3 months observation period. The food intake volume of OVX group increased remarkably at the first 2 months, but it became almost the same as the Sham groups after that. Therefor we cannot assert that only increase of the food consumption brings obesity. Then, we measured the body temperature as an index of the energy metabolism. The OVX group showed significant lower body temperature compared with the Sham group. This phenomenon means that the energy metabolism of the OVX group is lower than the Sham group. These results suggest that the cause of obesity in the OVX rats is a decrease in energy metabolism in addition to the increase of the food consumed.