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Analysis of cooperative functions of transporters andvesicle transport system in efflux of anticancer agents

Analysis of cooperative functions of transporters andvesicle transport system in efflux of anticancer agents
转运蛋白和囊泡转运系统在抗癌药物外排中的协同作用分析
批准号:
22501047
负责人:
FURUKAWA Tatsuhiko
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
We isolated human Rab27a and Rab27b cDNA. Human Rab27a, mousedominant negative mouse Rab2 or dominant negative mouse Rab9 expressing cells were established from ATP7A over expression cells respectively. We found the cells expressing ATP7B whose 6th metal binding domain was mutated were as sensitive as the parental cells to CDDP.
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DOI: 10.1038/bjc.2012.583
发表时间: 2013-01-15
期刊: BRITISH JOURNAL OF CANCER
影响因子: 8.8
作者: [Do, H. T. T., Koriyama, C., Khan, N. A., Higashi, M., Kato, T., Le, N. T., Matsushita, S., Kanekura, T., Akiba, S.]
通讯作者: Akiba, S.
DOI: 10.1289/ehp.1001899
发表时间: 2010-09
期刊: Environmental health perspectives
影响因子: 10.4
作者: [Takumi S, Komatsu M, Furukawa T, Ikeda R, Sumizawa T, Akenaga H, Maeda Y, Aoyama K, Arizono K, Ando S, Takeuchi T]
通讯作者: Takeuchi T
新規ベンズイミダゾール誘導体及びその用途
新型苯并咪唑衍生物及其用途
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: []
通讯作者:
DOI: 10.3892/ijmm.2013.1428
发表时间: 2013-09
期刊: International journal of molecular medicine
影响因子: 5.4
作者: [Yusuke Tajitsu;R. Ikeda;Yukihiko Nishizawa;Hirofumi Mataki;Xiao-Fang Che;T. Sumizawa;Mina Nitta;Tatsuya Yamaguchi;Masatatsu Yamamoto;Sho Tabata;S. Akiyama;Katsushi Yamada;T. Furukawa;Yasuo Takeda]
通讯作者: Yusuke Tajitsu;R. Ikeda;Yukihiko Nishizawa;Hirofumi Mataki;Xiao-Fang Che;T. Sumizawa;Mina Nitta;Tatsuya Yamaguchi;Masatatsu Yamamoto;Sho Tabata;S. Akiyama;Katsushi Yamada;T. Furukawa;Yasuo Takeda
87
    Nano-scale analysis of the drug transport mechanism of MRP1
    • 批准号:
      17590272
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2005
    • 负责人:
      FURUKAWA Tatsuhiko
    • 依托单位:
    Analysis of substrates transport mechanism and structural modification of MRP1
    • 批准号:
      14570123
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2002
    • 负责人:
      FURUKAWA Tatsuhiko
    • 依托单位:
    Analysis of the mechanisms for biological activities of thymidine phosphorylase
    • 批准号:
      12670144
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2000
    • 负责人:
      FURUKAWA Tatsuhiko
    • 依托单位:
    Identification and analysis of tyrosine phosphatase CD45 interacting proteins
    • 批准号:
      09680653
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.11万
    • 财政年份:
      1997
    • 负责人:
      FURUKAWA Tatsuhiko
    • 依托单位:
    海外基金