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Pathogenesis of newly described developmental abnormality induced in the kidney of rhesus monkey offspring by in utero and lactational e xposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Pathogenesis of newly described developmental abnormality induced in the kidney of rhesus monkey offspring by in utero and lactational e xposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
子宫内和哺乳期暴露于 2,3,7,8-四氯二苯并-对二恶英引起的恒河猴后代肾脏发育异常的发病机制
批准号:
22510073
负责人:
FUKUSATO Toshio
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
We for the first time described developmental abnormality with renal dysplasia induced in the kidney of rhesus monkey offspring exposed during prenatal and lactational period to TCDD. The renal lesions developed exclusively in offspring of dams exposed to relatively high dose (300ng/kg) of TCDD. We disclosed disturbed cox2-prostaglandin system as pathogenesis of the renal lesion.
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会议论文
Gestational and Lactational Exposure to 2,3,7,8-tetrachlorodibenzo-p-Dioxin (TCDD) Induces Abnormal Development of the Kidney in Offspring of Rhesus Monkeys
妊娠期和哺乳期接触 2,3,7,8-四氯二苯并-对二恶英 (TCDD) 会导致恒河猴后代肾脏发育异常
DOI: --
发表时间: 2011
期刊: Organohalogen Compounds
影响因子: --
作者: [Shunichiro Kubota, Toshio Fukusato]
通讯作者: Toshio Fukusato
Enhanced expression of cox2 and cyp1A1 in early active lesions developed in offspring of rhesus monkeys with exposure to 2,3,7,8-tetrachlorobenzo-p-dioxin (TCDD) during gestation and lactation
妊娠期和哺乳期接触 2,3,7,8-四氯苯并二恶英 (TCDD) 的恒河猴后代早期活动性病变中 cox2 和 cyp1A1 的表达增强
DOI: --
发表时间: 2012
期刊: Organohalogen Compounds
影响因子: --
作者: [Toshio Fukusato, Masato Watanabe,Shunichiro Kubota, Akihiro Arima, Atsunobu Muneoka, Hiroshi Sumida, Mineo Yasuda, Onouchi H, Toshio Fukusato]
通讯作者: Toshio Fukusato
ダイオキシンの胎生期および授乳期暴露後の仔アカゲザル腎におけるCox2、CYP1A1、HSP70 の発現
胎儿和哺乳期接触二恶英后幼恒河猴肾脏中 Cox2、CYP1A1 和 HSP70 的表达
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [渡邉雅人, 高橋芳久, 有馬昭宏, 宗岡篤信, 墨田 寛, 安田峯生, 久保田俊一郎, 福里利夫]
通讯作者: 福里利夫
Gestational and lactational exposure to2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces abnormal development of the kidney in offspring of rhesus monkeys
妊娠期和哺乳期接触 2,3,7,8-四氯二苯并-对二恶英 (TCDD) 会导致恒河猴后代肾脏发育异常
DOI: --
发表时间: 2011
期刊: Organohalogen Compounds
影响因子: --
作者: [Masato Watanabe, Shunichiro Kubota, Akihiro Arima, Atsunobu Muneoka,Hiroshi Sumida, Mineo Yasuda, Toshio Fukusato]
通讯作者: Toshio Fukusato
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