Detoxication of fluorine-bearing pharmaceutical drugs by advanced oxidation processes

含氟药物是一种内分泌干扰物，对水生态环境造成严重污染。添加臭氧和/或过氧化氢的高级氧化过程导致了对顽固化学物质的解毒。为了切断较强的C-F键，利用氧化镓催化的光助脱氟反应生成氟离子。负载铂的Ga2O_3催化剂提高了脱氟率。考察了脱氟的最佳条件。因此，Ames试验表明，难降解物质易矿化，其降解中间产物无致突变性。

Fluorine-bearing pharmaceuticals are acted as an endocrine disruptor to cause serious contamination in ecological aquatic environment. The advanced oxidation processes in the addition of ozone and/or hydrogen peroxide led the detoxication for recalcitrant chemicals. In order to sever the strong C-F bond, the photoassisted defluorination by gallium oxide catalysis was carried out to generate fluorine ions. The Pt-loading Ga2O3 catalyst enhanced the defluorination yield. The opimal conditions of defluorination were investigated. Therefore, non-degradable substances were easily mineralized and their degraded intermediates had no mutagenicity by the Ames test.