Detoxication of fluorine-bearing pharmaceutical drugs by advanced oxidation processes

高级氧化工艺对含氟药物的解毒

• 批准号: 22550141
• 负责人: HIDAKA Hisao
• 金额: $ 3.08万
• 依托单位: Meisei University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22550141/
• 关键词: オゾン酸化; 高度酸化技術; 光還元触媒; 医薬品汚染; 水質浄化; 含フッ素医薬品; 変異原性; 酸化ガリウム; 脱フッ素反応; 半導体光触媒; 医薬品分解; 水質汚染防止; 変異原性試験; 光触媒酸化; 向精神薬

Fluorine-bearing pharmaceuticals are acted as an endocrine disruptor to cause serious contamination in ecological aquatic environment. The advanced oxidation processes in the addition of ozone and/or hydrogen peroxide led the detoxication for recalcitrant chemicals. In order to sever the strong C-F bond, the photoassisted defluorination by gallium oxide catalysis was carried out to generate fluorine ions. The Pt-loading Ga2O3 catalyst enhanced the defluorination yield. The opimal conditions of defluorination were investigated. Therefore, non-degradable substances were easily mineralized and their degraded intermediates had no mutagenicity by the Ames test.

含氟药物作为内分泌干扰物，对生态水环境造成严重污染。添加臭氧和/或过氧化氢的高级氧化过程导致顽固化学物质的解毒。为了切断强C-F键，通过氧化镓催化进行光辅助脱氟以产生氟离子。负载Pt的Ga2O3催化剂提高了脱氟收率。研究了最佳脱氟条件。因此，不可降解物质很容易矿化，其降解中间体经Ames试验无致突变性。

项目成果

Enhanced remediation of simulated wastewaters contaminated with 2-chlorophenol and other aquatic pollutants TiO2-photoassisted ozonation in a sunlight-driven pilot scale photoreactor

在阳光驱动的中试规模光反应器中强化修复受 2-氯苯酚和其他水生污染物污染的模拟废水 TiO2 光辅助臭氧化

• 发表时间: 2011
• 期刊: Solar Energy
• 影响因子: 6.7
• 作者: T.Oyama;et.al.
• 通讯作者: et.al.

Optimization of advanced oxidation processes for recalcitrant chemicals by the hybrid O3/TiO2/UV procedure with a semi-pilot scaled solar reactor, PAOT (Photocatalytic and Advanced Oxidation Technologies for the treatment of water, Air

通过使用半中试规模太阳能反应器的混合 O3/TiO2/UV 程序，优化顽固化学品的高级氧化工艺，PAOT（用于处理水、空气的光催化和高级氧化技术）

• 发表时间: 2011
• 作者: H. Hidaka;T. Koike;Y. Mitsutsuka;N. Serpone;and T. Oyama
• 通讯作者: and T. Oyama

Photooxidation of the antidepressant drug Fluoxetine (Prozac®) in aqueous media by hybrid catalytic/ozonation processes.

• DOI: 10.1016/j.watres.2011.02.030
• 发表时间: 2011-04
• 期刊: Water research
• 影响因子: 12.8
• 作者: Fabiola Méndez-Arriaga;Tomohiko Otsu;T. Oyama;J. Giménez;S. Esplugas;H. Hidaka;N. Serpone

Binary Cationic BDDAC/Anionic DoS Surfactant Systems of Variable Components. Mineralization by an Advanced Oxidation Process in Aqueous Dispersions.

可变组分的二元阳离子 BDDAC/阴离子 DoS 表面活性剂体系。

• 发表时间: 2010
• 期刊: J. Adv. Oxid. Technol.
• 作者: H. Hidaka;T. Tamano;T. Fujimoto;T.Machinami;T. Oyama;T. Horiuchi and N. Serpone
• 通讯作者: T. Horiuchi and N. Serpone

オゾンを併用した光触媒による残留医薬品の光分解

利用臭氧光催化剂光分解残留药物

• 发表时间: 2012
• 作者: 大津智彦;肥田野康行;小池崇喜;大山俊之;日高久夫
• 通讯作者: 日高久夫