Integration of pleiotropic signals involved in the telomere integrity

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CST (Cdc13-Stn1-Ten1) complex of the budding yeast Saccharomyces cerevisiae has been shown to associate with the telomeric DNA ends and to be involved in telomere replication and protection. Stn1 was phosphorylated by Cdk during specific times during the cell cycle, and the phosphorylation regulated telomere elongation negatively. In addition, we found that an stn1 mutant defective in its protective function resulted in telomere elongation via the recombination- and telomerase-dependent mechanisms. Moreover, we found that telomere shortening-mediated cellular senescence induced autophagy by regulating the TOR-signaling pathway and the telomere-binding protein Rap1.