Role of H-ficolin. A recognition molecule in innate immunity

H-ficolin 的作用。

• 批准号: 22570144
• 负责人: ENDO Yuichi
• 金额: $ 2.75万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22570144/
• 关键词: 免疫学; 生体分子; 蛋白質; レクチン; 補体; 成体分子

To define the role of human H-ficolin in vivo, we generated a model mouse, ficolins A/B double-deficient mouse transiently expressing H-ficolin. In the serum, H-ficolin formed the complexes with serine proteases MASPs and sMAP. H-ficolin recognized a bacterial strain, Streptococcus pneumonia D39, and led to complement activation on this bacterium. The susceptibility of this mouse to bacterial infection is in progress. These results suggest that H-ficolin is involved in first defense against bacterial infection.

为了确定人H-纤维胶凝蛋白在体内的作用，我们产生了模型小鼠，瞬时表达H-纤维胶凝蛋白的纤维胶凝蛋白A/B双缺陷小鼠。在血清中，H-纤维胶凝蛋白与丝氨酸蛋白酶MASPs和sMAP形成复合物。H-纤维胶凝蛋白识别细菌菌株，肺炎链球菌D39，并导致该细菌上的补体激活。该小鼠对细菌感染的易感性正在进行中。这些结果表明，H-纤维胶凝蛋白参与了对细菌感染的第一防御。

项目成果

認識分子Ficolin欠損マウスの表現型

识别分子 Ficolin 缺陷的小鼠表型

• 发表时间: 2010
• 作者: 遠藤雄一;松坂友裕;石田由美;岩城大輔;高橋実;松下操;藤田禎三
• 通讯作者: 藤田禎三

Mouse ficolin B has an ability to form complexes with mannose-binding lectin-associated serine proteases and activate complement through the lectin pathway.

• DOI: 10.1155/2012/105891
• 发表时间: 2012
• 期刊: Journal of biomedicine & biotechnology
• 作者: Endo Y;Iwaki D;Ishida Y;Takahashi M;Matsushita M;Fujita T
• 通讯作者: Fujita T

補体レクチン経路と凝固系の協調作用-補体系研究の新展開-

补体凝集素途径与凝血系统的合作 - 补体系统研究新进展 -

• 发表时间: 2011
• 期刊: 日本血栓止血学会誌
• 作者: T. Yoshida;H. Tsuge;H. Konno;T.Hisabori;Y. Sugano;Takashi Kamachi;遠藤雄一
• 通讯作者: 遠藤雄一

L-Ficolin Binds to the Glycoproteins Hemagglutinin and Neuraminidase and Inhibits Influenza A Virus Infection Both in vitro and in vivo

• DOI: 10.1159/000335670
• 发表时间: 2012-01-01
• 期刊: JOURNAL OF INNATE IMMUNITY
• 影响因子: 5.3
• 作者: Pan, Qin;Chen, Haidan;Zhang, Xiao-Lian
• 通讯作者: Zhang, Xiao-Lian

Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement.

甘露糖结合凝集素相关的丝氨酸蛋白酶1/3的机理的补体途径激活。

• DOI: 10.1016/j.molimm.2011.08.021
• 发表时间: 2011-10
• 期刊: Molecular immunology
• 影响因子: 3.6
• 作者: Banda NK;Takahashi M;Takahashi K;Stahl GL;Hyatt S;Glogowska M;Wiles TA;Endo Y;Fujita T;Holers VM;Arend WP
• 通讯作者: Arend WP