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ANALYSIS OF EVOLUTIONARY MECHANISM OF DLX3 GENE CO-OPTION IN DEVELOPMENT OF NOVEL APPENDAGES OF VERTEBRATES

ANALYSIS OF EVOLUTIONARY MECHANISM OF DLX3 GENE CO-OPTION IN DEVELOPMENT OF NOVEL APPENDAGES OF VERTEBRATES
脊椎动物新型附肢发育中DLX3基因共选择的进化机制分析
批准号:
22570218
负责人:
SUMIYAMA Kenta
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Through Dlx3-4 gene enhancer analysis, we found that (1) the core element of brachial arch enhancer I37-2 was conserved between mice and platypus, and branchial arch activity was acquired in placental mammal lineage. (2) I37-1 that shows limbs and hair follicles enhancer activities is quite ancient, conserved even in amphioxus. The core motif plays an important role in Dlx3 gene co-option in development of limbs and hair follicles
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会议论文
"Loss-of-function mutation in a repressor module of human- specifically activated enhancer HACNS1."
“人类特异性激活的增强子 HACNS1 的抑制子模块发生功能丧失突变。”
DOI: 10.1093/molbev/msr231
发表时间: 2011
期刊: Molecular Biology and Evolution
影响因子: 10.7
作者: [Anbutsu H, Nikoh N, Tanaka K, Fukatsu T, 鹿児嶋久美子・津田みどり・山田直隆・Wu L-H・Wang C-P・Wu J-W・Chen Z-Q・Teramoto K・Kumashiro B・Buranapanichpan S, Kenta Sumiyama and Naruya Saitou]
通讯作者: Kenta Sumiyama and Naruya Saitou
Function and evolution of paralogous conserved regulatory elements of Gsx homeobox genes
Gsx同源盒基因旁系同源保守调控元件的功能和进化
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Y. Aki, M. Nagai, Y. Nagai, K. Imai, M. Aki, A. Sato, M. Kubo, S. Nagatomo and T. Kitagawa, 隅山健太]
通讯作者: 隅山健太
The Genetic Basis For Primate Evolution At Cis-Regulatory System Level.
顺式调控系统水平上灵长类动物进化的遗传基础。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Sumiyama, K.]
通讯作者: K.
DOI: 10.1371/journal.pone.0043785
发表时间: 2012
期刊: PloS one
影响因子: 3.7
作者: [Nakanishi A, Kobayashi N, Suzuki-Hirano A, Nishihara H, Sasaki T, Hirakawa M, Sumiyama K, Shimogori T, Okada N]
通讯作者: Okada N
25
    Evolutionary analysis on regulatory mechanism of the Dlx3-7 gene cluster regarding evolution of morphological novelty.
    • 批准号:
      18570007
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.5万
    • 财政年份:
      2006
    • 负责人:
      SUMIYAMA Kenta
    • 依托单位: