Linkage between ribosome synthesis and vesicle transport

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To understand the linkage between ribosome biogenesis and other cellular systems, we investigated functions of trans-acting factors of ribosome biogenesis, Rrs1 and Ebp2. We found that Rrs1 and Ebp2 are localized at the periphery of the nuclear membrane and function on maintenance of telomereorganization. We also found that GSK3 protein kinases constitute the phosphorylation cascade in the signal transduction pathway due to secretory defects, where Rrs1 and Ebp2 are involved.