Toxicity and antitumor effects of parasporin-4 from Bacillus thuringiensis strain A1470

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Parasporin-4 (PS4) is a cytotoxic protein produced by Bacillus thuringiensis A1470 strain. It exhibits specific cytotoxicity against human cancer cell lines especially CACO-2, Sawano, and MOLT-4 cells. And it does not exhibit the activity against 4 normal tissue cells such as human primary hepatocyte cells, UtSMC, MRC-5, and normal T cells. However, these results do not provide assurance that the protein exhibits no toxicity to mammals. In this study, we determined acute toxicity and effects of long-term administration of PS4 on mouse. In addition, we tested the inhibitory effects of oral administration of pre-PS4 against colon cancer on mutant mice.