Structural changes accompanying mitigation of the allergic action ofovomucoid after passing an electric current

卵粘蛋白是引起母鸡鸡蛋过敏的最主要的过敏原，含有S-S键，可能与其过敏作用有关。用皮肤刺激法评价该蛋白在阳极侧和阴极侧的变态反应均有所减弱。用基质结合激光解吸/电离飞行时间质谱仪对电解后的卵粘蛋白进行修饰，发现有两个不同的多肽片段(57E-63K、，123H-128R)丢失。虽然卵粘蛋白中的总游离SH基团在病侧增加，但本研究尚未确定S-S键的断裂区域

Ovomucoid is the most prominent allergen causing hen’s eggallergy, containing S-S bonds that may be responsible for its allergic action. Theallergic action of this protein has been reduced after electrolysis on both the anodeand the cathode sides when evaluated by mean of skin prick. The results for modificationsof ovomucoid after electrolysis showed two distinct peptide fragments （57E-63K、123H-128R）had lost with matrix-associated laser desorption/ionization time-of-flight massspectrometry. Although the total free SH groups in ovomucoid were increased on thecathode side, the regions for breaking S-S bonds have not been determined in this study