Structural changes accompanying mitigation of the allergic action ofovomucoid after passing an electric current

卵类粘蛋白是引起鸡蛋过敏的最主要的过敏原，其含有的S-S键可能是其过敏作用的原因。当通过皮肤针刺评价时，这种蛋白质的过敏作用在阳极侧和阴极侧电解后都降低了。利用基质相关激光解吸电离飞行时间质谱（MALDI-TOF MS）对卵类粘蛋白进行电化学修饰，结果显示有两个不同的肽段（57 E-63 K，123 H-128 R）丢失。尽管卵类粘蛋白中总的游离巯基在阴极侧增加，但本研究中尚未确定S-S键断裂的区域

Ovomucoid is the most prominent allergen causing hen’s eggallergy, containing S-S bonds that may be responsible for its allergic action. Theallergic action of this protein has been reduced after electrolysis on both the anodeand the cathode sides when evaluated by mean of skin prick. The results for modificationsof ovomucoid after electrolysis showed two distinct peptide fragments （57E-63K、123H-128R）had lost with matrix-associated laser desorption/ionization time-of-flight massspectrometry. Although the total free SH groups in ovomucoid were increased on thecathode side, the regions for breaking S-S bonds have not been determined in this study