Screening for antifungal agents from microbial origin using a silkwormmodel of Candida infection

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The in vivo-mimic assay system using silkworm larvae was performed as the primary screening tool to discover antibiotics against Candida albicans. Microbial culture broths were screened in this in vivo-mimic assay system, and a new antifungal compound, designated BF-0003C, was isolated from the culture broth of Penicillium sp. BF-0003. BF-0003 had potent anti-C. albicans activity by the agar diffusion method with an inhibition zone of 22 mm at 10 μg/6 mm disk. Furthermore, C. albicans-infected silkworms survived when BF-0003C was injected at 25 to 100 μg/larva.