Functional bioimaging of brain microglia by purine receptor PET ligands

嘌呤受体 PET 配体对脑小胶质细胞的功能生物成像

• 批准号: 22590053
• 负责人: MAEDA Jun
• 金额: $ 2.91万
• 依托单位: National Institute of Radiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590053/
• 关键词: 陽電子撮像法; P2Y12受容体; アデノシンA2a受容体; ミクログリア; アルツハイマー病; 陽電子断層撮像法（PET）; プリン受容体; アデノシン受容体; 陽電子断層撮像法(PET)

To visualize the microglial cells in the brain using positron emission tomography (PET), the development and preclinical evaluation of purinergic receptor PET ligands have been demonstrated. P2Y12 receptor ligand [11C]clopidogrel and adenosine A2a ligand [11C]TMSX have been investigated, however both ligands fail to detect the microglial cells in the brain.

为了使用正电子发射断层扫描 (PET) 可视化大脑中的小胶质细胞，嘌呤能受体 PET 配体的开发和临床前评估已经得到证实。 P2Y12 受体配体 [11C]氯吡格雷和腺苷 A2a 配体 [11C]TMSX 已被研究，然而这两种配体均未能检测到大脑中的小胶质细胞。

项目成果

Positron Emission Tomography Measurement of Dopamine D2 Receptor Occupancy in the Pituitary and Cerebral Cortex: Relation to Antipsychotic-Induced Hyperprolactinemia

• DOI: 10.4088/jcp.08m04307yel
• 发表时间: 2010-09-01
• 期刊: JOURNAL OF CLINICAL PSYCHIATRY
• 影响因子: 5.3
• 作者: Arakawa, Ryosuke;Okumura, Masaki;Suhara, Tetsuya
• 通讯作者: Suhara, Tetsuya

Altered serotonin release and serotonin 1A receptor density in CaMKIIα-deficient mice assessed by a comparison of in vivo PET and in vitro autoradiographic data

通过比较体内 PET 和体外放射自显影数据评估 CaMKIIα 缺陷小鼠血清素释放和血清素 1A 受体密度的改变

• 发表时间: 2012
• 作者: Jun Maeda;Masaki Tokunaga;Ming-Rong Zhang;Takeharu Minamihisamatsu;Toshimitsu Fukumura;Tsuyoshi Miyakawa;Tetsuya Suhara;Makoto Higuchi
• 通讯作者: Makoto Higuchi

PET Imaging of glial activation and neuroinflammation in dementia and other neurological disorders by translocator protein (TSPO) ligands

通过易位蛋白 (TSPO) 配体对痴呆和其他神经系统疾病中的神经胶质活化和神经炎症进行 PET 成像

• 发表时间: 2012
• 作者: Jun Maeda;Masaki Tokunaga;Ming-Rong Zhang;Takeharu Minamihisamatsu;Toshimitsu Fukumura;Tsuyoshi Miyakawa;Tetsuya Suhara;Makoto Higuchi;岡本麻依,長谷川智津,中山祐治,武田祐美,盛永敬郎,福本泰典,山口直人;馬場照彦;Nakazawa S;Jun Maeda
• 通讯作者: Jun Maeda

Glial Cell-Mediated Deterioration and Repair of the Nervous System after Traumatic Brain Injury in a Rat Model as Assessed by Positron Emission Tomography

• DOI: 10.1089/neu.2009.1196
• 发表时间: 2010-08-01
• 期刊: JOURNAL OF NEUROTRAUMA
• 影响因子: 4.2
• 作者: Yu, Iwae;Inaji, Motoki;Suhara, Tetsuya
• 通讯作者: Suhara, Tetsuya

PET Applications in Animal Models of Neurodegenerative and Neuroinflammatory Disorders

PET 在神经退行性和神经炎症性疾病动物模型中的应用

• DOI: 10.1007/7854_2011_167
• 发表时间: 2012
• 期刊: Curr Top Behav Neurosci
• 作者: Higuchi M;Maeda J;Ji B;Tokunaga M;Zhang MR;Maruyama M;Ono M;Fukumura T;Suhara T
• 通讯作者: Suhara T