Functional analysis of MDGA family proteins on corticogenesis.

MDGA 家族蛋白对皮质生成的功能分析。

• 批准号: 22590055
• 负责人: YAMAMOTO Tohru
• 金额: $ 3万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590055/
• 关键词: 大脳皮質; 細胞移動; 発生分化; 神経細胞; 組織構築

MDGA1 encodes a GPI-anchored IgSF molecule containing MAM domain, which we isolated as a gene expressed by a specific subset of spinal and DRG neurons. In mouse cerebral cortex, MDGA1 is selectively expressed by neurons located in the upper layer. To investigate the function of MDGA1 and MDGA2, the other family member of MDGA1, in corticogenesis, we generated the MDGA1 and MDGA2 deficient mice. The migration of MDGA1/2-mutant neurons to the superficial cortical plate was clearly delayed, indicating that MDGA family proteins are involved in radial migration of projection neurons. The results also indicated that MDGA1 was expressed by and required for a subset of upper layer neurons for their proper migration. Theses observations suggested that radial migration of upper layer neurons in the cortical plate might be differentially regulated among cell types.

MDGA1编码一个含有MAM结构域的GPI锚定的IGSF分子，我们将其分离为由脊柱和DRG神经元的特定子集表达的基因。在小鼠大脑皮层中，MDGA1由位于上层的神经元选择性表达。为了研究MDGA1的另一家家庭成员MDGA1和MDGA2的功能，在皮质生成中，我们产生了MDGA1和MDGA2缺陷小鼠。 MDGA1/2突变神经元向浅表皮质板的迁移明显延迟，表明MDGA家族蛋白参与投影神经元的径向迁移。结果还表明，MDGA1是由上层神经元子集的适当迁移所必需的，并且需要。这些观察结果表明，皮质板中上层神经元的径向迁移可能在细胞类型之间受到差异调节。

项目成果

Expression and localization of Alcadein Along with X11L and APP in mouse brain

Alcadein 与 X11L 和 APP 在小鼠脑中的表达和定位

• 发表时间: 2010
• 作者: Yi Piao;Naoya Gotoh;Maho Kondo;Yuhki Saito;Saori Hata;Tohru Yamamoto;Toshiharu Suzuki
• 通讯作者: Toshiharu Suzuki

Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.

• DOI: 10.1002/ana.22343
• 发表时间: 2011-06
• 期刊: ANNALS OF NEUROLOGY
• 影响因子: 11.2
• 作者: Hata, Saori;Fujishige, Sayaka;Araki, Yoichi;Taniguchi, Miyako;Urakami, Katsuya;Peskind, Elaine;Akatsu, Hiroyasu;Araseki, Masahiko;Yamamoto, Kazuo;Martins, Ralph N.;Maeda, Masahiro;Nishimura, Masaki;Levey, Allan;Chung, Kathryn A.;Montine, Thomas;Leverenz, James;Fagan, Anne;Goate, Alison;Bateman, Randall;Holtzman, David M.;Yamamoto, Tohru;Nakaya, Tadashi;Gandy, Sam;Suzuki, Toshiharu
• 通讯作者: Suzuki, Toshiharu

Enhanced amyloidogenic processing of APP in Alcadein-deficient mice

Alcadein 缺陷小鼠中 APP 的淀粉样蛋白生成过程增强

• 发表时间: 2011
• 作者: Gotoh;N.;Saito;Y.;Hata;S.;Yamamoto;T.;Suzuki;T
• 通讯作者: T

A small peptide sequence is sufficient for nitiating kinesin-1 activation through part of TPR region of KLC1

小肽序列足以通过 KLC1 的部分 TPR 区域启动驱动蛋白-1 激活

• 发表时间: 2012
• 期刊: Traffic
• 影响因子: 4.5
• 作者: Kawano T;Araseki M;Araki Y;Kinjo M;Yamamoto T;Suzuki T
• 通讯作者: Suzuki T

Ascending spinal tract formation in developing chick.

发育中的雏鸡上行脊髓束的形成。

• 发表时间: 2010
• 作者: Guo;X.;et al.;Arakawa T
• 通讯作者: Arakawa T