Role of interlukin-1 in the cytotoxicity of intact Mycobacterium tuberculosis against host cells

本研究表明，结核分枝杆菌感染细胞产生的活性氧和活性氮通过感染宿主细胞产生促炎细胞因子、白介素1和肿瘤坏死因子-α，部分导致宿主细胞死亡。在真核细胞中使用蛋白质合成抑制剂的实验表明，来自受感染宿主细胞的其他因素也对这种细胞毒性事件起到了作用。

This study revealed that reactive oxygen species and reactive nitrogen species from Mycobacterium tuberculosis infected cells partly causes the host cell death, through the production of pro-inflammatory cytokines, interleukin-1 and tumor necrosis factor-alpha from the infected host cell. Experiments using an inhibitor of protein synthesis in eukaryote, indicated that other factors from the infected host cells also contributed to this cytotoxic event.