Possible metabolic activation of arsenic carcinogenesis ?New mode of activation of dimethylarsenic involved with sulfur atom-

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One theory concerning the modes of action is that the biotransformation of dimethylmonothioarsinic acid (DMTA) from dimethylarsinic acid (DMA) plays an important role in the carcinogenesis. However, the mechanisms of in vivo formation and disappearance of DMTA, and its toxicity are not fully understood. Thus, the purpose of the present study was to clarify the mechanismof metabolic formation of DMTA from DMA. DMTA is produced from trivalent dimethylated arsenic but not DMA by rhodanese. DMTA is easily re-converted into DMA by trace elements with a powerful affinity for sulfur. The metabolic process of DMA to DMMTA consists of a complicated mode of interaction between trace metals and/or sulfur transferase.