Tissue-specificity of arsenic carcinogenesis - Production mechanism of reactive oxygen species in target organs of arsenic carcinogenesis -

砷致癌的组织特异性 - 砷致癌靶器官中活性氧的产生机制 -

• 批准号: 12672178
• 负责人: YAMANAKA Kenzo
• 金额: $ 1.73万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12672178/
• 关键词: 8-oxodG; oxidative stress; dimethylarsinic acid; arsenic; carcinogenesis; arsenic; 無機砒素; ジメチル砒素; 8-OHdG; ジメチル砒素過酸化ラジカル

Recent studies have indicated that oral administration of dimethylarsinic acid (DMA) to rats led to a higher incidence of 8-oxo-2'-deoxyguanosine (8-oxodG) formation in liver and kidney. Therefore, we focused our attention on the induction of oxidative damage in skin, lung, liver and urinary b adder the target organs in arsenic carcinogenesis. The present study is to establish a mouse animal model to understand the mechanism of human arsenic carcinogenesis through the production of oxidative damage. The present findings that the formation of 8-oxodG was observed in skin, lung, liver and urinary bladder in our animal model would be useful for the understanding the arsenic carcinogenesis mechanism in relation to the formation of free radical species.

最近的研究表明，大鼠口服二甲基砷酸(DMA)后，肝脏和肾脏中8-氧-2‘-脱氧鸟苷(8-oxodG)的形成发生率较高。因此，我们关注砷致癌过程中皮肤、肺、肝脏和尿液等靶器官氧化损伤的诱导。本研究旨在建立一种小鼠动物模型，通过氧化损伤的产生来了解人类砷致癌的机制。8-oxodG在动物模型的皮肤、肺、肝脏和膀胱中的形成有助于理解砷的致癌机制与自由基物种的形成有关。

项目成果

Kenzo Yamanaka et al.: "Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-oxo-2'-deoxyguanpsine level specifically in the target organs for arsenic carcinogenesis"Biochemical and Biophysical

Kenzo Yamanaka 等人：“小鼠口服二甲基胂酸（无机砷的主要代谢物）会导致砷致癌的靶器官中 8-氧代-2-脱氧鸟嘌呤水平升高”《生物化学与生物物理》

Kenzo Yamanaka 他5名: "Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-oxo-2'-deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis"Biochemical and Biophysical Re

Kenzo Yamanaka 等 5 人：“小鼠口服二甲基砷酸（无机砷的主要代谢物）会导致 8-oxo-2-脱氧鸟苷水平增加，特别是在砷致癌的靶器官中”Biochemical and Biophysical Re

山中 健三 ら 他5名: "Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-oxo-2'-deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis"Biochemical and Biophysical Research

Kenzo Yamanaka 和其他 5 人：“小鼠口服二甲基胂酸（无机砷的主要代谢物）会导致 8-oxo-2-脱氧鸟苷水平增加，特别是在砷致癌的靶器官中”生物化学和生物物理研究