Tissue-specificity of arsenic carcinogenesis - Production mechanism of reactive oxygen species in target organs of arsenic carcinogenesis -

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Recent studies have indicated that oral administration of dimethylarsinic acid (DMA) to rats led to a higher incidence of 8-oxo-2'-deoxyguanosine (8-oxodG) formation in liver and kidney. Therefore, we focused our attention on the induction of oxidative damage in skin, lung, liver and urinary b adder the target organs in arsenic carcinogenesis. The present study is to establish a mouse animal model to understand the mechanism of human arsenic carcinogenesis through the production of oxidative damage. The present findings that the formation of 8-oxodG was observed in skin, lung, liver and urinary bladder in our animal model would be useful for the understanding the arsenic carcinogenesis mechanism in relation to the formation of free radical species.