Inhibitory effects of losartan on arachidonic acid metabolism via cytochrome P450(CYP) enzymes

结果表明，治疗高血压的药物氯沙坦可通过抑制细胞色素P450(CYP)S产生的花生四烯酸(EETs)减少环氧二十碳三烯酸(EETs)的生成，与氯沙坦类似的替米沙坦也有这种抑制作用。EETs具有心脏保护作用。因此，我们认为EETs的减少可能与这些药物的心律失常等心血管副作用有关。

It was shown that losartan, a drug of the treatment for hypertension, decrease the production of epoxyeicosatrienoic acids (EETs) from arachidonic acid by inhibiting some cytochrome P450 (CYP)s. This inhibitory effect was also found in telmisartan, which is the similar anti-hypertensive as losartan. EETs have cardioprotective effects. Therefore, it was suggested that the decrease of EETs production would be related tothe cardiovascular side effects such as arrhythmia of these drugs.