Analysis of the functions of the membrane protein basigin during spermatogenesis and in spermagozoa

为了分析basigin在睾丸和精子中的作用，我们在小鼠睾丸和精子中寻找能与basigin结合的分子。结果表明，basigin不与单羧酸转运体（MCT） 1共定位，而与MCT2共定位。此外，与睾丸型基底蛋白相比，精子型基底蛋白缺乏部分igg样C2结构域。这也表明精子头部和尾部的沐浴素是不同的。

To analyze the function of the basigin in the testis and sperm, we searched molecules which could bind to the basigin in the mouse testis and sperm. The results indicated that basigin did not co-localize with monocarboxylate transporter (MCT) 1, but with MCT2. Further, sperm-type basigin lacks a part of Ig-like C2 domain, compared to the testis-type basigin. It is also suggested that basigin in the sperm head is different from that in the sperm tail.