Molecular Cell Biology of a Novel SignalingSystem in Neurons

我分析了神经胶质细胞中初级纤毛的各种功能，并阐明了神经元初级纤毛。关于初级纤毛信号传递过程潜在的分子机制的新发现，可能为从神经元-神经胶质细胞相互作用的角度进行分析铺平道路。此外，刺激剂对Hedgehog受体刺激神经元初级纤毛引起细胞内振荡，这可能导致细胞去分化。我将在未来的项目中进一步关注这一有趣的现象。

I analyzed various functions of primary cilia in glial cells, in addition to the elucidation of neuronal primary cilia. Thesenovel findings on the molecular mechanisms underlying the signaling processes throughprimary cilia may pave the way into analysis in terms of neuron-glia interaction. Furthermore, stimulation of neuronal primary cilia with agonist to Hedgehog receptors provoked intracellular oscillation that may lead to dedifferentiation of the cells. I will further focus on this intriguing phenomenon in future project.