Molecular Cell Biology of a Novel SignalingSystem in Neurons

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I analyzed various functions of primary cilia in glial cells, in addition to the elucidation of neuronal primary cilia. Thesenovel findings on the molecular mechanisms underlying the signaling processes throughprimary cilia may pave the way into analysis in terms of neuron-glia interaction. Furthermore, stimulation of neuronal primary cilia with agonist to Hedgehog receptors provoked intracellular oscillation that may lead to dedifferentiation of the cells. I will further focus on this intriguing phenomenon in future project.