Functional role of the transient receptor potential canonical (TRPC) channels in the development of cardiac ischemia/reperfusion injury
瞬时受体电位经典(TRPC)通道在心脏缺血/再灌注损伤发展中的功能作用
基本信息
- 批准号:22590205
- 负责人:
- 金额:$ 2.83万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2010
- 资助国家:日本
- 起止时间:2010 至 2012
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Ca2+overload has been implicated in the pathogenesis of ischemia/reperfusion injury in the heart. The present investigation used Langendorff perfusion method of mouse hearts and fluorescence Ca2+imaging of mouse ventricular myocytes and revealed that the transient receptor potential canonical (TRPC) channels mediate the Ca2+entry responsible for Ca2+overload during the reperfusion of ischemic myocardium. These observations indicate that TRPC channel blockade could provide potential new avenues to develop strategies for protecting the heart during reperfusion of ischemic myocardium.
钙超载参与了心脏缺血/再灌注损伤的发病机制。本研究采用小鼠心脏的Langendorff灌流法和小鼠心肌细胞的荧光钙显像法,发现在缺血心肌再灌流过程中,瞬时受体电位通道(TRPC)介导了导致钙超载的钙内流。这些观察表明,TRPC通道阻断可能为开发缺血心肌再灌注期间的心脏保护策略提供潜在的新途径。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Sevoflurane protects ventricular myocytes from Ca2+paradox-mediated Ca2+overload by blocking the activation of transient receptor potential canonical channels
七氟烷通过阻断瞬时受体电位经典通道的激活,保护心室肌细胞免受 Ca2 悖论介导的 Ca2 超载
- DOI:10.1097/aln.0b013e31822b7901
- 发表时间:2011
- 期刊:
- 影响因子:8.8
- 作者:Kojima A;Kitagawa H;Omatsu-Kanbe M,Matsuura H;Nosaka S
- 通讯作者:Nosaka S
Nosaka S. Sevoflurane protects cardiomyocyte from Ca2+paradox by preserving SR Ca2+and blocking TRPC channel
Nosaka S.七氟烷通过保留 SR Ca2 并阻断 TRPC 通道来保护心肌细胞免受 Ca2 悖论
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Kojima A;Kitagawa H;Omatsu-Kanbe M;Matsuura H
- 通讯作者:Matsuura H
Ca2+ paradox injury mediated through TRPC channels in mouse ventricular myocytes
- DOI:10.1111/j.1476-5381.2010.00986.x
- 发表时间:2010-12-01
- 期刊:
- 影响因子:7.3
- 作者:Kojima, Akiko;Kitagawa, Hirotoshi;Nosaka, Shuichi
- 通讯作者:Nosaka, Shuichi
The improved effect of hypothermic cultivation on the functional expression of human cardiac Kv1.5 channels
低温培养对人心脏Kv1.5通道功能表达的改善作用
- DOI:
- 发表时间:2013
- 期刊:
- 影响因子:0
- 作者:Ding W-G;Xie Y;Toyoda F;Bai JY. Matsuura H
- 通讯作者:Bai JY. Matsuura H
Ischemic survival and constitutively active autophagy in self-beating atypically-shaped cardiomyocytes (ACMs): characterization of a new subpopulation of heart cells
- DOI:10.1007/s12576-012-0236-5
- 发表时间:2012-10
- 期刊:
- 影响因子:0
- 作者:M. Omatsu-Kanbe;H. Matsuura
- 通讯作者:M. Omatsu-Kanbe;H. Matsuura
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MATSUURA Hiroshi其他文献
MATSUURA Hiroshi的其他文献
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{{ truncateString('MATSUURA Hiroshi', 18)}}的其他基金
Evaluation of floor slipperiness and influential analysis of gait
地板打滑程度评价及对步态的影响分析
- 批准号:
24500668 - 财政年份:2012
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Creation of a high active surface using three-dimensional self-assembly of metallic particles and its application to environmental catalyst
金属颗粒三维自组装高活性表面及其在环境催化剂中的应用
- 批准号:
23510117 - 财政年份:2011
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of pronunciation training method using speech recognition for the hearing impaired
开发利用语音识别的听障人士发音训练方法
- 批准号:
22500513 - 财政年份:2010
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular basis for the regulation of the cardiac delayed rectifier K^+ channel by membrane PIP_2
膜PIP_2调节心脏延迟整流K^通道的分子基础
- 批准号:
17590185 - 财政年份:2005
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Regulation of the cardiac delayed rectifier K^+ channel by membrane PIP_2 and its physiological significance
膜PIP_2对心脏延迟整流K^通道的调节及其生理意义
- 批准号:
15590184 - 财政年份:2003
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Regulation of the cardiac delayed rectifier K^+ channel by membrane phosphoinositides
膜磷酸肌醇对心脏延迟整流 K^ 通道的调节
- 批准号:
13670042 - 财政年份:2001
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Properties and role of the delayed rectifier K^+ current in the pacemaker activity
延迟整流器 K^ 电流在起搏器活动中的特性和作用
- 批准号:
11670040 - 财政年份:1999
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An analysis of the enhancement of delayed rectifier K^+ current by P_2-purinoceptor stimulation
P_2-嘌呤受体刺激增强延迟整流K^电流的分析
- 批准号:
09670048 - 财政年份:1997
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of Slow Releasing Anticancer Drug Based with Absorbable Biomaterial Chit*
基于可吸收生物材料 Chit 的缓释抗癌药物的开发*
- 批准号:
04807093 - 财政年份:1992
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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