Study for ATP-driven transport mechanism of ABC transporters based on the "ATP hydrolysis switch" hypothesis.
Study for ATP-driven transport mechanism of ABC transporters based on the "ATP hydrolysis switch" hypothesis.
批准号:
22590212
负责人:
SOHMA Yoshiro
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
研究CFTR通道(ABC转运蛋白超家族的成员)的ATP依赖性门控动力学,详细揭示了ATP水解循环(产生的化学能)和孔门控循环(消耗的机械能)之间的松散耦合,
英文摘要
Investigating the ATP-dependent gating kinetics of CFTR channel, a member of ABC transporter superfamily in detail revealed a loose coupling between ATP-hydrolysis cycle (chemical energy generated) and the pore gating cycle (mechanical energy consumed) as
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A stable ATP binding to nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR
ATP 与核苷酸结合域的稳定结合对于 ABC 转运蛋白 CFTR 中可靠的门控循环非常重要
DOI:
--
发表时间:
2010
期刊:
Journal of Physiological Sciences
影响因子:
2.3
作者:
[Shimizu H, Yu YC, Sohma Y, et al]
通讯作者:
et al
Curcumin : Biosynthesis, Medicinal Uses and Health Benefits(Eds Sasaki & Kichida)
姜黄素:生物合成、医药用途和健康益处(佐佐木编辑)
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Sohma Y, et al]
通讯作者:
et al
高速AFM によるCFTR チャネルの動態観察
使用高速 AFM 观察 CFTR 通道动态
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Yamashita H, Mio K, Mio M, Uchihashi T, Yasui M, Ando T, Sohma Y]
通讯作者:
Sohma Y
ABCトランスポータ・CFTRチャネルにおけるATP加水分解の成否を決めている作動サイクル中間状態
决定 ABC 转运蛋白/CFTR 通道中 ATP 水解成功或失败的操作循环的中间状态
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[相馬義郎, 6人中6番目]
通讯作者:
6人中6番目
A hidden intermediate state for priming ATP-hydrolysis during open conformation in CFTR channels
CFTR 通道开放构象期间引发 ATP 水解的隐藏中间状态
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Sohma Y, Yu YC, Yasui M, Hwang TC.]
通讯作者:
Hwang TC.
共 19 条
Development of technical basis for direct observations of membrane protein complex in dynamic equilibrium under a physiological condition
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批准号:15K15035
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2015
-
负责人:SOHMA Yoshiro
-
依托单位:
Study for mechanism of ABC transporters based on single molecular direct observations using high speed Atomic Force Microscopy.
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批准号:25293049
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.9万
-
财政年份:2013
-
负责人:SOHMA Yoshiro
-
依托单位:
Mechanism of Nucleotide Binding Domain engine in ABC transporters
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批准号:19590215
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2007
-
负责人:SOHMA Yoshiro
-
依托单位:
Effects of hydrophobic compounds on anion channels expressed in pancreatic duct cells
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批准号:15590196
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.37万
-
财政年份:2003
-
负责人:SOHMA Yoshiro
-
依托单位:
海外基金