The role andmechanism of central AMPK on sleep homeostasis and body temperature regulation

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AMPK, a cellular energy sensor, is activated by 6-hour sleep deprivation. Intra cerebro ventricular injection of AICAR, an enhancer of AMPK, induces the enhancement of EEG slow wave acticity (SWA) during NREM sleep, while compound C, an inhibitor of AMPK, induces suppression of SWA. These data indicate the involvement of AMPK on sleep homeostasis. However, the activation of AMPK caused by starvation do not change the EEG SWA. Furthermore, in PPARa KO mice, above-mentioned AMPK-related drugs do not work, suggesting that the role of AMPK on the sleep homeostasis needs PPARa function.