Metabolic Cycles Are Linked to the Cardiovascular Diurnal Rhythm in Rats with Essential Hypertension

最近的证据表明，代谢和心血管节律受到重叠的分子途径的调节，表明代谢周期的失调可以使血压（BP）的正常昼夜节律去同步化。然而，很少有人知道的影响，代谢周期的变化对血压昼夜节律。在本研究中，我们发现自发性高血压大鼠（SHR），发展为原发性高血压与昼夜血压节律紊乱，表现出衰减的进食节律。更重要的是，纠正SHR的异常摄食节律恢复了每日血压节律。这些结果表明，代谢周期是心血管昼夜节律的重要决定因素。

Recent evidence has suggested that the metabolic and cardiovascular rhythms are subject to regulation by overlapping molecular pathways, indicating that dysregulation of metabolic cycles could desynchronize the normal diurnal rhythm of blood pressure (BP). However, little is known about the impact of changes in metabolic cycles on BP diurnal rhythm. In the present study, we found that spontaneously hypertensive rats (SHR), which develop essential hypertension with disrupted diurnal BP rhythms, exhibit attenuated feeding rhythm. More importantly, the correction of abnormal feeding rhythms in SHR restored the daily BP rhythm. These results indicate that the metabolic cycle is an important determinant of the cardiovascular diurnal rhythm.