Regulation of inflammation and metabolism by vitamin Dreceptor in hepatic immune cells

维生素D受体（VDR）对维生素D3和胆汁酸石胆酸的活性形式作出反应。我们研究了VDR在肝脏免疫细胞中的作用。VDR对胆汁淤积小鼠肝脏代谢和免疫相关基因的调节作用有限。在VDR缺失小鼠的肠道中，炎症反应受到抑制。在VDR缺失小鼠肝脏的单核细胞中观察到NK细胞和iNKT细胞增加。结果显示VDR在精氨酸-肝脏途径中的作用。

Vitamin D receptor (VDR) responds to the active form of vitamin D3 and the bile acid lithocholic acid. We investigated the role of VDR in hepatic immune cells. VDR played a limited role in regulation of hepatic genes involved in metabolism and immunity in mice with cholestasis. Inflammatory responses were suppressed in the intestine of VDR-null mice. Increased NK cells and iNKT cells were observed in mononuclear cells from the liver of VDR-null mice. The results show a role of VDR in the intestine-liver pathway.