A role of dbpA, DNA binding protein in Hodgkin lymphoma

DbpA，DNA-binding protein A is belived to be involved in DNA recombination in E.Coli.We found dbpA is highly expressed in CD30 positive lymphocytes，which is restricted to activated lymphocyte in normal tissue.Also dbpA is highlyexpressed in CD30+lymphoma，classical Hodgkin lymphoma and anaplastic lymphoma.As it is well known that constitutive activation of NF·B signaling is a characteristic feature of Hodgkin lymphoma，dbpA seemed to act in a downstream molecule of NF·B signaling pathway.

dbpA, DNA-binding protein A is belived to be involved in DNA recombination in E.Coli. We found dbpA is highly expressed in CD30 positive lymphocytes, which is restricted to activated lymphocyte in normal tissue. Also dbpA is highlyexpressed in CD30+lymphoma, classical Hodgkin lymphoma and anaplastic lymphoma. As it is well known that constitutive activation of NF・B signaling is a characteristic feature of Hodgkin lymphoma, dbpA seemed to act in a downstream molecule of NF・B signaling pathway.