Immune regulation by controlling vesicular functions in dendritic cells

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Plasmacytoid dendritic cells (pDCs) trigger autoimmune diseases by producing a large amount of IFN-alpha in response to nucleic acid. We found that the proteasome inhibitor bortezomib and the tyrosine kinase inhibitor dasatinib suppressed the IFN-alpha production by disturbing vesicular transport of nucleic acid-sensing Toll-like receptors and that of nucleic acid ligands, respectively. We thus obtained fundamental findings to develop novel immunosuppressants targeting vesicular functions in pDCs.