Development of effective hematopoietic stem cell transplantation/cellular immunotherapy for adult T-cell leukemia
Development of effective hematopoietic stem cell transplantation/cellular immunotherapy for adult T-cell leukemia
批准号:
17016034
负责人:
KADOWAKI Norimitsu
金额:
$35.84万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
Adult T-cell leukemia (ATL) caused by a retrovirus HTLV-I has long been intractable. We aimed to develop novel therapies that exploit allogeneic and autologous immune responses to ATL cells in this study. First we clarified prognostic factors in allogeneic stem cell transplantation for ATL by a nationwide retrospective study. Furthermore, we identified several novel ATL-associated antigens that are promising as targets for immunotherapy. We performed three clinical trials of DC-based immunotherapy for acute myeloid leukemia. Through these efforts, we established the basis to develop novel cellular immunotherapies for ATL.
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DOI:
10.1097/01.cji.0000190169.61416.f5
发表时间:
2006-03
期刊:
Journal of Immunotherapy
影响因子:
3.9
作者:
[K. Kawamura;N. Kadowaki;R. Suzuki;S. Udagawa;S. Kasaoka;N. Utoguchi;T. Kitawaki;N. Sugimoto;N. Okada;K. Maruyama;T. Uchiyama]
通讯作者:
K. Kawamura;N. Kadowaki;R. Suzuki;S. Udagawa;S. Kasaoka;N. Utoguchi;T. Kitawaki;N. Sugimoto;N. Okada;K. Maruyama;T. Uchiyama
シンポジウム移植幹細胞の選択.
移植干细胞选择研讨会。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[一戸辰夫]
通讯作者:
一戸辰夫
Clinical Significance of Severity and Subcategory of Chronic GVHD Evaluated by NIH Consensus Criteria.
根据 NIH 共识标准评估慢性 GVHD 严重程度和亚类的临床意义。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Sato T, Ichinohe T, Ishikawa T, Uchiyama T, 他3名]
通讯作者:
他3名
当院における成人T細胞白血病症例の後方視的解析
我院成人T细胞白血病病例回顾性分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[内山達樹、菱澤方勝、一戸辰夫、門脇則光、石川隆之、内山卓, 他7名]
通讯作者:
他7名
Toward the application of dendritic cells to tumor immunotherapy. Symposium "Dendritic cell"
树突状细胞在肿瘤免疫治疗中的应用。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Miyabe Y., Narita Y., Mizowaki T., Matsuo Y., Takayama K., Takahashi K., Kaneko S., Kawada N., Maruhashi A., Hiraoka M., Kadowaki N]
通讯作者:
Kadowaki N
共 85 条
Immune regulation by controlling vesicular functions in dendritic cells
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批准号:22590434
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2010
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负责人:KADOWAKI Norimitsu
-
依托单位:
Analysis of myeloid suppressor cells in tumor-bearing mice and humans and in patients after chemotherapy
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批准号:17590994
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
-
财政年份:2005
-
负责人:KADOWAKI Norimitsu
-
依托单位:
Thansfection of oncogenes into dendritic cells utilizing receptor-mediated endocytosis of liposomes
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批准号:15591004
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2003
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负责人:KADOWAKI Norimitsu
-
依托单位:
Recovery of Natural Interferon-α/β-producing Cells after Allogeneic Hematopoietic Stem Cell Transplantation
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批准号:13671062
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2001
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负责人:KADOWAKI Norimitsu
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依托单位:
海外基金