Development andapplication of the new clinical laboratory procedure using saliva at home medical care-For the prevention of senile pneumonia-

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Both CRP and human beta defensin(hBD) concentration in saliva were used for the early detection and prevention of senile pneumonia. CRP was recognized as an inflammatory marker of pneumonia and hBD, as an index of thecleanliness level in oral cavity, respectively. We found a good association between CRP measured in saliva and serum of an inflammatory disorder patients (r=0.88,P < 0.001). Furthermore, when the transferrin concentration in saliva was limited to a less than 1 mg/ml sample, the association was become stronger (r=0.96,P < 0.001). Moreover, some pretreating methods of saliva were examined for the measurement of hBD with positive charge. Tween 20 and diluted hydrochloric acid were used to release hBD from negative charged matter, such as muchin. Measurement of the exact hBD concentration in salivawas attained by this pretreating method. These results suggested that saliva test would be useful for the early detection and prevention of senile pneumonia.