Effect on the suppression to diarrhea by hydrogen derived from the fermentation of intestinal microbes by the ingestion of nondigestible oligosaccharide.

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Non-pathogenic diarrhea is often induced by the enteral nutrition and antibiotic treatment. We have already clarified that the induction of osmotic diarrhea was suppressed by the ingestion of nondigestible oligosaccharide. In this study we examined the interaction among the suppression to diarrhea and the change in intestinal microflora by the ingestion of fructooligosaccharide using modeled animals that induce the diarrhea. It was suggested that the suppression for diarrhea interacted among the higher excretion of hydrogen gas, the better levels of oxidative stress markers, inflammatory cytokines, and lower activities of harmful enzymes derived from intestinal microbes. We believe that the nondigestible saccharides can contribute the improvement of the liquid formula.